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Uqcc1 ubiquinol-cytochrome c reductase complex assembly factor 1 [ Mus musculus (house mouse) ]

Gene ID: 56046, updated on 2-Nov-2024

Summary

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Official Symbol
Uqcc1provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 1provided by MGI
Primary source
MGI:MGI:1929472
See related
Ensembl:ENSMUSG00000005882 AllianceGenome:MGI:1929472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bfzb; Bfzp; Cbp3; Uqcc; 2310079L17Rik; 2410003P15Rik; 3110038N19Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex III assembly. Located in cytoplasmic vesicle. Is expressed in several structures, including eye and nervous system. Orthologous to human UQCC1 (ubiquinol-cytochrome c reductase complex assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 12.1), cerebellum adult (RPKM 6.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uqcc1 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155688806..155772230, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155846886..155930310, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene family with sequence similarity 83, member C Neighboring gene predicted gene, 54125 Neighboring gene STARR-seq mESC enhancer starr_06151 Neighboring gene STARR-seq mESC enhancer starr_06152 Neighboring gene growth differentiation factor 5 Neighboring gene centrosomal protein 250 Neighboring gene predicted gene, 50621

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain. Vetter K, et al. Mech Dev, 2001 Jan. PMID 11118897
  2. Genetic mapping of a mouse modifier gene that can prevent ALS onset. Kunst CB, et al. Genomics, 2000 Dec 1. PMID 11112346
  3. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase complex assembly factor 1
Names
basic FGF repressed, zinc binding protein
basic FGF-repressed Zic-binding protein
ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355441.1 → NP_001342370.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform c. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL845445
    UniProtKB/TrEMBL
    A6PWX7
    Conserved Domains (1) summary
    pfam03981
    Location:37 → 172
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  2. NM_001355442.1 → NP_001342371.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform c. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL845445
    UniProtKB/TrEMBL
    A6PWX7
    Conserved Domains (1) summary
    pfam03981
    Location:37 → 172
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  3. NM_001355443.1 → NP_001342372.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AL845445
    UniProtKB/TrEMBL
    A6PWX8
    Conserved Domains (1) summary
    pfam03981
    Location:152 → 291
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  4. NM_018888.4 → NP_061376.2  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform a

    See identical proteins and their annotated locations for NP_061376.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice junction in the 5' end compared to variant 4. The resulting isoform (a) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AK139488, BB761198
    Consensus CDS
    CCDS16957.2
    UniProtKB/Swiss-Prot
    A2ARK1, Q3TET9, Q9CRP2, Q9CWU6, Q9JK78
    UniProtKB/TrEMBL
    A6PWX9
    Related
    ENSMUSP00000105264.5, ENSMUST00000109636.11
    Conserved Domains (1) summary
    pfam03981
    Location:132 → 271
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155688806..155772230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251889.1 → XP_030107749.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X4

    Conserved Domains (1) summary
    pfam03981
    Location:132 → 196
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  2. XM_011239706.3 → XP_011238008.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X3

    Conserved Domains (1) summary
    pfam03981
    Location:152 → 216
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  3. XM_006499922.4 → XP_006499985.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X2

    Conserved Domains (1) summary
    pfam03981
    Location:132 → 194
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

  4. XM_011239705.3 → XP_011238007.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X1

    Conserved Domains (1) summary
    pfam03981
    Location:152 → 214
    Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

RNA

  1. XR_003953679.1 RNA Sequence

    Related
    ENSMUST00000136933.8

  2. XR_003953678.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWU6.1 GenPept UniProtKB/Swiss-Prot:Q9CWU6

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