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MYDGF myeloid derived growth factor [ Homo sapiens (human) ]

Gene ID: 56005, updated on 5-May-2024

Summary

Official Symbol
MYDGFprovided by HGNC
Official Full Name
myeloid derived growth factorprovided by HGNC
Primary source
HGNC:HGNC:16948
See related
Ensembl:ENSG00000074842 MIM:606746; AllianceGenome:HGNC:16948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL25; IL27; SF20; IL27w; C19orf10; R33729_1; EUROIMAGE1875335
Summary
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 37.2), prostate (RPKM 33.6) and 25 other tissues See more
Orthologs
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Genomic context

Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4657545..4670342, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4641702..4654500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4657557..4670354, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4639529-4640528 Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4660681-4661180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4661482-4662252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4675983-4676943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4679601-4680102 Neighboring gene DPP9 antisense RNA 1 Neighboring gene dipeptidyl peptidase 9 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4694063-4695262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:4703720-4704919 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:4713085-4714284 Neighboring gene uncharacterized LOC105372250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9903 Neighboring gene tRNA-Gly (anticodon TCC) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myeloid-derived growth factor
Names
UPF0556 protein C19orf10
interleukin 27 working designation
interleukin-25
stromal cell-derived growth factor SF20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019107.4NP_061980.1  myeloid-derived growth factor precursor

    See identical proteins and their annotated locations for NP_061980.1

    Status: VALIDATED

    Source sequence(s)
    AK098829, BC014655
    Consensus CDS
    CCDS12133.1
    UniProtKB/Swiss-Prot
    D6W628, O75256, O75272, Q969H8, Q9BTK7, Q9NP69
    UniProtKB/TrEMBL
    M0QYN0
    Related
    ENSP00000262947.2, ENST00000262947.8
    Conserved Domains (1) summary
    pfam10572
    Location:40171
    UPF0556; Uncharacterized protein family UPF0556

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4657545..4670342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026987.2XP_016882476.1  myeloid-derived growth factor isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4641702..4654500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321457.1XP_054177432.1  myeloid-derived growth factor isoform X1