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AZF1 azoospermia factor 1 [ Homo sapiens (human) ]

Gene ID: 560, updated on 31-Aug-2024

Summary

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Official Symbol
AZF1provided by HGNC
Official Full Name
azoospermia factor 1provided by HGNC
Primary source
MIM:415000
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZF; SP3; AZFA

Genomic context

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Location:
Yq11

Bibliography

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Related articles in PubMed

  1. AZF gene microdeletions in azoospermic-oligozoospermic males. Lahoz Alonso R, et al. Med Clin (Barc), 2023 Feb 24. PMID 35999075
  2. Association of azoospermia factor region deletions in infertile male subjects among Malaysians. Hussein AA, et al. Andrologia, 2015 Mar. PMID 24528375
  3. Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China. Ye JJ, et al. J Zhejiang Univ Sci B, 2013 Sep. PMID 24009201, Free PMC Article
  4. [Relationship between follicle stimulating hormone and AZF microdeletion on Y chromosome in patients with azoospermia or severe oligozoospermia]. Wang XQ, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2011 Oct. PMID 21983735
  5. [Sequence tagged sites of AZFc microdeletion in Chinese Han population]. Wu Q, et al. Zhonghua Nan Ke Xue, 2011 May. PMID 21837945

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Y-chromosome haplogroups and Azoospermia Factor (AZF) analysis in Tunisian infertile male.
    Title: Y-chromosome haplogroups and Azoospermia Factor (AZF) analysis in Tunisian infertile male.
  2. AZF microdeletion affects semen parameters, sex hormone levels, and chromosome karyotypes in infertile men in Xinjiang.
    Title: AZF microdeletion affects semen parameters, sex hormone levels, and chromosome karyotypes in infertile men in Xinjiang.
  3. [Analysis of copy number variation in AZF region of Y chromosome in patients with spermatogenic failure].
    Title: [Analysis of copy number variation in AZF region of Y chromosome in patients with spermatogenic failure].
  4. High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis.
    Title: High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis.
  5. DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia.
    Title: DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia.
  6. AZF gene microdeletions in azoospermic-oligozoospermic males.
    Title: AZF gene microdeletions in azoospermic-oligozoospermic males.
  7. We investigated partial deletion of AZFc region and DAZ copy number in a population of Iranian infertile men and normozoospermic controls. Partial AZFc deletions were not significantly different between the infertile and normozoospermic men.
    Title: Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
  8. AZFd deletions were found to be significant (P < 0.05) in male infertility and it may be associated with other types of AZF deletions.
    Title: Association of azoospermia factor region deletions in infertile male subjects among Malaysians.
  9. genetic association study in population in China: Data suggest b2/b3 partial deletions (both deletion-only and deletion-duplication) in AZFc (azoospermia factor c region) are associated with infertility due to spermatogenic impairment (azoospermia).
    Title: Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment.
  10. male infertility is associated with partial AZFc duplications, but neither gr/gr nor b2/b3 deletions, suggesting that partial AZFc duplications rather than deletions are risk factors for male infertility in the Chinese-Yi population
    Title: Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Associated conditions

Description Tests
azoospermia factor 1
OMIM: 415000GeneReviews: Not available

General gene information

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Property

  • phenotype only

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