U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc1a4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 55963, updated on 18-Apr-2024

Summary

Official Symbol
Slc1a4provided by MGI
Official Full Name
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4provided by MGI
Primary source
MGI:MGI:2135601
See related
Ensembl:ENSMUSG00000020142 AllianceGenome:MGI:2135601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SATT; ASCT1; ASCT-1
Summary
Enables L-aspartate transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in L-aspartate import across plasma membrane. Acts upstream of or within serine import across plasma membrane. Located in intermediate filament. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; nose; and thymus primordium. Orthologous to human SLC1A4 (solute carrier family 1 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.1), whole brain E14.5 (RPKM 9.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
11 A3.1; 11 12.97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20252180..20282713, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20302180..20332713, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 68 Neighboring gene STARR-positive B cell enhancer ABC_E6955 Neighboring gene predicted gene, 39604 Neighboring gene STARR-seq mESC enhancer starr_28794 Neighboring gene ribosomal proteimn L12-ps2 Neighboring gene STARR-positive B cell enhancer ABC_E6956 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 39605

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-alanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-serine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-serine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-serine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in hydroxyproline transport ISO
Inferred from Sequence Orthology
more info
 
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within serine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in threonine transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutral amino acid transporter A
Names
alanine/serine/cysteine/threonine transporter 1
solute carrier family 1 member 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428788.1NP_001415717.1  neutral amino acid transporter A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL662926
  2. NM_018861.4NP_061349.3  neutral amino acid transporter A isoform 1

    See identical proteins and their annotated locations for NP_061349.3

    Status: VALIDATED

    Source sequence(s)
    AL662926
    Consensus CDS
    CCDS24457.1
    UniProtKB/Swiss-Prot
    O35874
    UniProtKB/TrEMBL
    Q3US35, Q3UTP8, Q8BXT5, Q9ESU8
    Related
    ENSMUSP00000105223.2, ENSMUST00000109594.8
    Conserved Domains (1) summary
    pfam00375
    Location:44477
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    20252180..20282713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)