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Dclre1a DNA cross-link repair 1A [ Mus musculus (house mouse) ]

Gene ID: 55947, updated on 2-Nov-2024

Summary

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Official Symbol
Dclre1aprovided by MGI
Official Full Name
DNA cross-link repair 1Aprovided by MGI
Primary source
MGI:MGI:1930042
See related
Ensembl:ENSMUSG00000025077 AllianceGenome:MGI:1930042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pso2; Snm1; Smn1a; mKIAA0086; 2810043H12Rik
Summary
Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Acts upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 4.9), liver E14.5 (RPKM 4.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dclre1a in Genome Data Viewer
Location:
19 D2; 19 51.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56517593..56536716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56529161..56548284, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family S member 1 Neighboring gene predicted gene, 53193 Neighboring gene NHL repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_46527 Neighboring gene STARR-seq mESC enhancer starr_46528 Neighboring gene predicted gene, 32441 Neighboring gene predicted gene, 52389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Ahkter S, et al. Mol Cell Biol, 2005 Nov. PMID 16260620, Free PMC Article
  2. The eukaryotic Pso2/Snm1/Artemis proteins and their function as genomic and cellular caretakers. Bonatto D, et al. Braz J Med Biol Res, 2005 Mar. PMID 15761611
  3. Mammalian SNM1 is required for genome stability. Hemphill AW, et al. Mol Genet Metab, 2008 May. PMID 18180189, Free PMC Article
  4. The multifunctional SNM1 gene family: not just nucleases. Yan Y, et al. Future Oncol, 2010 Jun. PMID 20528238, Free PMC Article
  5. SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Akhter S, et al. Biochem Biophys Res Commun, 2008 Dec 5. PMID 18848520, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snm1 is a tumor suppressor in mice that in addition has a role in immunity
    Title: Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.
  2. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation
    Title: Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0086

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-lactamase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-lactamase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
DNA cross-link repair 1A protein
Names
DNA cross-link repair 1A, PSO2 homolog
SNM1 homolog A
beta-lactamase MBLAC2
NP_001347366.2
NP_001347367.2
NP_001347368.1
NP_061301.4
XP_006527280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360437.2 → NP_001347366.2  DNA cross-link repair 1A protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166746
    Consensus CDS
    CCDS29917.2
    UniProtKB/Swiss-Prot
    Q571H5, Q6GQR6, Q9JIC3
    UniProtKB/TrEMBL
    S4R1N2, S4R1T3
    Related
    ENSMUSP00000138364.3, ENSMUST00000182059.3
    Conserved Domains (2) summary
    pfam07522
    Location:903 → 1008
    DRMBL; DNA repair metallo-beta-lactamase
    cl23716
    Location:678 → 833
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  2. NM_001360438.2 → NP_001347367.2  DNA cross-link repair 1A protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166746
    UniProtKB/Swiss-Prot
    Q571H5, Q6GQR6, Q9JIC3
    Conserved Domains (1) summary
    cl23716
    Location:678 → 784
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  3. NM_001360439.1 → NP_001347368.1  DNA cross-link repair 1A protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166746
    Conserved Domains (2) summary
    pfam07522
    Location:385 → 490
    DRMBL; DNA repair metallo-beta-lactamase
    cl23716
    Location:160 → 315
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  4. NM_018831.5 → NP_061301.4  DNA cross-link repair 1A protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166746
    Consensus CDS
    CCDS29917.2
    UniProtKB/Swiss-Prot
    Q571H5, Q6GQR6, Q9JIC3
    UniProtKB/TrEMBL
    S4R1N2, S4R1T3
    Related
    ENSMUSP00000138290.3, ENSMUST00000182276.3
    Conserved Domains (2) summary
    pfam07522
    Location:903 → 1008
    DRMBL; DNA repair metallo-beta-lactamase
    cl23716
    Location:678 → 833
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RNA

  1. NR_153439.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166746
    Related
    ENSMUST00000183143.9

  2. NR_153440.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166746

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56517593..56536716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527217.3 → XP_006527280.1  DNA cross-link repair 1A protein isoform X1

    See identical proteins and their annotated locations for XP_006527280.1

    UniProtKB/Swiss-Prot
    Q571H5, Q6GQR6, Q9JIC3
    Conserved Domains (2) summary
    pfam07522
    Location:921 → 1026
    DRMBL; DNA repair metallo-beta-lactamase
    cl23716
    Location:696 → 851
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RNA

  1. XR_877682.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIC3.2 GenPept UniProtKB/Swiss-Prot:Q9JIC3

Gene LinkOut

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