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sacm1la SAC1 like phosphatidylinositide phosphatase a [ Danio rerio (zebrafish) ]

Gene ID: 558940, updated on 12-Sep-2024

Summary

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Official Symbol
sacm1laprovided by ZNC
Official Full Name
SAC1 like phosphatidylinositide phosphatase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-122
See related
Ensembl:ENSDARG00000015290 AllianceGenome:ZFIN:ZDB-GENE-060503-122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sacm1lb; si:ch211-222e23.8
Summary
Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 19
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (26966001..27006774, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27383684..27422541, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 12, tandem duplicate 1 Neighboring gene zinc finger and BTB domain containing 12, tandem duplicate 2 Neighboring gene tumor necrosis factor a (TNF superfamily, member 2) Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol-3-phosphatase SAC1-A
Names
SAC1 suppressor of actin mutations 1-like a
phosphatidylinositide phosphatase SAC1-A
phosphatidylinositide phosphatase SAC1-B
phosphatidylinositol-4-phosphate phosphatase
suppressor of actin mutations 1-like protein A
suppressor of actin mutations 1-like protein B
NP_001038343.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044878.2 → NP_001038343.2  phosphatidylinositol-3-phosphatase SAC1-A

    Status: VALIDATED

    Source sequence(s)
    CR933768, FP102194
    UniProtKB/Swiss-Prot
    A4VCH0, Q1L8A6
    Related
    ENSDARP00000083973.5, ENSDART00000089540.6
    Conserved Domains (1) summary
    COG5329
    Location:56 → 526
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    26966001..27006774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4VCH0.2 GenPept UniProtKB/Swiss-Prot:A4VCH0

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