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GPRC5C G protein-coupled receptor class C group 5 member C [ Homo sapiens (human) ]

Gene ID: 55890, updated on 3-Nov-2024

Summary

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Official Symbol
GPRC5Cprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Cprovided by HGNC
Primary source
HGNC:HGNC:13309
See related
Ensembl:ENSG00000170412 MIM:605949; AllianceGenome:HGNC:13309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAIG3; RAIG-3
Summary
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 15.6), thyroid (RPKM 14.0) and 21 other tissues See more
Orthologs
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Genomic context

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See GPRC5C in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74432088..74451658)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75322628..75342195)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72428227..72447797)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72382905-72383799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390282-72390782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390783-72391283 Neighboring gene Sharpr-MPRA regulatory region 691 Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72420638-72421138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72422872-72423636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72448210-72449201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72449202-72450192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72450947-72451617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12706 Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene CD300a molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene CD300 molecule like family member b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPRC5C drives branched-chain amino acid metabolism in leukemogenesis. Zhang YW, et al. Blood Adv, 2023 Dec 26. PMID 37639313, Free PMC Article
  2. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Amisten S, et al. Endocr J, 2017 Mar 31. PMID 28228611
  3. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Bräuner-Osborne H, et al. Genomics, 2000 Apr 15. PMID 10783259
  4. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Robbins MJ, et al. Genomics, 2000 Jul 1. PMID 10945465
  5. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Bräuner-Osborne H, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311935

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle HDA PubMed 

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member C
Names
orphan G-protein coupled receptor
retinoic acid responsive gene protein
retinoic acid-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366261.2 → NP_001353190.1  G-protein coupled receptor family C group 5 member C isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform c.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS92388.1
    UniProtKB/TrEMBL
    A0A0C4DFY5, A8MXZ4
    Conserved Domains (1) summary
    cd15277
    Location:48 → 305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  2. NM_001366262.2 → NP_001353191.1  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS11699.2
    UniProtKB/Swiss-Prot
    B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
    UniProtKB/TrEMBL
    A0A0C4DFY5
    Conserved Domains (1) summary
    cd15277
    Location:48 → 305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  3. NM_018653.5 → NP_061123.4  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS11699.2
    UniProtKB/Swiss-Prot
    B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
    UniProtKB/TrEMBL
    A0A0C4DFY5
    Related
    ENSP00000376405.3, ENST00000392629.3
    Conserved Domains (1) summary
    cd15277
    Location:48 → 305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  4. NM_022036.4 → NP_071319.3  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS11699.2
    UniProtKB/Swiss-Prot
    B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
    UniProtKB/TrEMBL
    A0A0C4DFY5
    Related
    ENSP00000376403.2, ENST00000392627.7
    Conserved Domains (1) summary
    cd15277
    Location:48 → 305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74432088..74451658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436400.1 → XP_047292356.1  G-protein coupled receptor family C group 5 member C isoform X3

    UniProtKB/TrEMBL
    A8MXZ4
    Related
    ENSP00000376404.3, ENST00000392628.7

  2. XM_047436398.1 → XP_047292354.1  G-protein coupled receptor family C group 5 member C isoform X1

  3. XM_047436399.1 → XP_047292355.1  G-protein coupled receptor family C group 5 member C isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791806.1 Reference GRCh38.p14 PATCHES

    Range
    8536..28106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333233.1 → XP_054189208.1  G-protein coupled receptor family C group 5 member C isoform X3

    UniProtKB/TrEMBL
    A8MXZ4

  2. XM_054333231.1 → XP_054189206.1  G-protein coupled receptor family C group 5 member C isoform X1

  3. XM_054333232.1 → XP_054189207.1  G-protein coupled receptor family C group 5 member C isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75322628..75342195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316669.1 → XP_054172644.1  G-protein coupled receptor family C group 5 member C isoform X3

    UniProtKB/TrEMBL
    A8MXZ4

  2. XM_054316667.1 → XP_054172642.1  G-protein coupled receptor family C group 5 member C isoform X1

  3. XM_054316668.1 → XP_054172643.1  G-protein coupled receptor family C group 5 member C isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQ84.2 GenPept UniProtKB/Swiss-Prot:Q9NQ84

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