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GPRC5C G protein-coupled receptor class C group 5 member C [ Homo sapiens (human) ]

Gene ID: 55890, updated on 24-Nov-2020

Summary

Official Symbol
GPRC5Cprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Cprovided by HGNC
Primary source
HGNC:HGNC:13309
See related
Ensembl:ENSG00000170412 MIM:605949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAIG3; RAIG-3
Summary
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 15.6), thyroid (RPKM 14.0) and 21 other tissues See more
Orthologs

Genomic context

See GPRC5C in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74431350..74451658)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72427480..72447797)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 142 Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene CD300a molecule Neighboring gene CD300 molecule like family member b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
G-protein coupled receptor family C group 5 member C
Names
orphan G-protein coupled receptor
retinoic acid responsive gene protein
retinoic acid-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366261.2NP_001353190.1  G-protein coupled receptor family C group 5 member C isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform c.
    Source sequence(s)
    AC079325
    Related
    ENSP00000376404.3, ENST00000392628.7
    Conserved Domains (1) summary
    cd15277
    Location:48305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
  2. NM_001366262.2NP_001353191.1  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Conserved Domains (1) summary
    cd15277
    Location:48305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
  3. NM_018653.5NP_061123.4  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS42378.1
    Related
    ENSP00000376405.3, ENST00000392629.3
    Conserved Domains (1) summary
    cd15277
    Location:48305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
  4. NM_022036.4NP_071319.3  G-protein coupled receptor family C group 5 member C isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2 and 4 encode isoform a.
    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS11699.1
    Related
    ENSP00000376403.2, ENST00000392627.7
    Conserved Domains (1) summary
    cd15277
    Location:48305
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74431350..74451658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257514.2XP_005257571.1  G-protein coupled receptor family C group 5 member C isoform X4

    Conserved Domains (1) summary
    pfam00003
    Location:106190
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. XM_005257512.2XP_005257569.1  G-protein coupled receptor family C group 5 member C isoform X1

    Conserved Domains (1) summary
    pfam00003
    Location:161245
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
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