Format

Send to:

Choose Destination

GABRQ gamma-aminobutyric acid type A receptor subunit theta [ Homo sapiens (human) ]

Gene ID: 55879, updated on 3-May-2020

Summary

Official Symbol
GABRQprovided by HGNC
Official Full Name
gamma-aminobutyric acid type A receptor subunit thetaprovided by HGNC
Primary source
HGNC:HGNC:14454
See related
Ensembl:ENSG00000268089 MIM:300349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THETA
Summary
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017]
Expression
Biased expression in brain (RPKM 1.4), adrenal (RPKM 0.9) and 4 other tissues See more
Orthologs

Genomic context

See GABRQ in Genome Data Viewer
Location:
Xq28
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152637895..152659828)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151806637..151821825)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene microRNA 105-2 Neighboring gene keratin 8 pseudogene 8 Neighboring gene uncharacterized LOC105373370 Neighboring gene MAGE family member A4 pseudogene Neighboring gene MAGE family member A3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129629, MGC129630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
 
chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter transporter activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-aminobutyric acid receptor subunit theta
Names
GABA(A) receptor subunit theta
gamma-aminobutyric acid (GABA) A receptor, theta
gamma-aminobutyric acid type A receptor theta subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015965.2 RefSeqGene

    Range
    5001..20180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018558.4NP_061028.3  gamma-aminobutyric acid receptor subunit theta precursor

    See identical proteins and their annotated locations for NP_061028.3

    Status: REVIEWED

    Source sequence(s)
    AC244102, AF189259
    Consensus CDS
    CCDS14707.1
    UniProtKB/Swiss-Prot
    Q9UN88
    Related
    ENSP00000469332.1, ENST00000598523.3
    Conserved Domains (1) summary
    cl27321
    Location:60353
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152637895..152659828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531184.3XP_011529486.1  gamma-aminobutyric acid receptor subunit theta isoform X1

    Conserved Domains (2) summary
    pfam02931
    Location:60265
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:272354
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Support Center