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CBWD1 COBW domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55871, updated on 5-Sep-2021

Summary

Official Symbol
CBWD1provided by HGNC
Official Full Name
COBW domain containing 1provided by HGNC
Primary source
HGNC:HGNC:17134
See related
Ensembl:ENSG00000172785 MIM:611078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COBP
Expression
Ubiquitous expression in thyroid (RPKM 21.1), adrenal (RPKM 19.5) and 25 other tissues See more
Orthologs
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Genomic context

See CBWD1 in Genome Data Viewer
Location:
9p24.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (120837..179083, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (120837..179075, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1388 Neighboring gene uncharacterized LOC105375942 Neighboring gene forkhead box D4 Neighboring gene VISTA enhancer hs628 Neighboring gene uncharacterized LOC105375943 Neighboring gene DOCK8 antisense RNA 1 Neighboring gene dedicator of cytokinesis 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
COBW domain-containing protein 1
Names
COBW-like protein
NPC-A-6 COBW domain-containing protein 1
cobalamin synthase W domain-containing protein 1
cobalamin synthetase W domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145355.1NP_001138827.1  COBW domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001138827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK290648, AL356244, BC005996, BU621970
    Consensus CDS
    CCDS47948.1
    UniProtKB/Swiss-Prot
    Q9BRT8
    Related
    ENSP00000323433.10, ENST00000314367.14
    Conserved Domains (1) summary
    COG0523
    Location:11340
    YejR; GTPase, G3E family [General function prediction only]
  2. NM_001145356.1NP_001138828.1  COBW domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001138828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF212253, AL356244, AY343911, BC005996, BU621970
    Consensus CDS
    CCDS47947.1
    UniProtKB/Swiss-Prot
    Q9BRT8
    Related
    ENSP00000371885.4, ENST00000382447.8
    Conserved Domains (3) summary
    COG0523
    Location:42357
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:255354
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_018491.5NP_060961.3  COBW domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060961.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL356244, AL449043
    Consensus CDS
    CCDS6438.1
    UniProtKB/Swiss-Prot
    Q9BRT8
    Related
    ENSP00000348915.4, ENST00000356521.8
    Conserved Domains (2) summary
    COG0523
    Location:42376
    YejR; GTPase, G3E family [General function prediction only]
    cl26601
    Location:1962
    ABC_ATPase; Predicted ATPase of the ABC class

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    120837..179083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251513.4XP_005251570.1  COBW domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    COG0523
    Location:42356
    YejR; GTPase, G3E family [General function prediction only]
    pfam02492
    Location:43211
    cobW; CobW/HypB/UreG, nucleotide-binding domain
    pfam07683
    Location:254353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  2. XM_005251515.1XP_005251572.1  COBW domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A087X140
    Related
    ENSP00000483870.1, ENST00000613508.4
    Conserved Domains (3) summary
    COG0523
    Location:42328
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:226325
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005251514.1XP_005251571.1  COBW domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:245344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011517962.3XP_011516264.1  COBW domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    COG0523
    Location:42317
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011517961.2XP_011516263.1  COBW domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    COG0523
    Location:11321
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:219318
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:11171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011517963.1XP_011516265.1  COBW domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    pfam07683
    Location:126225
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:183
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_011517964.3XP_011516266.1  COBW domain-containing protein 1 isoform X9

    Related
    ENSP00000482821.1, ENST00000616944.4
    Conserved Domains (2) summary
    COG0523
    Location:42208
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_005251517.5XP_005251574.1  COBW domain-containing protein 1 isoform X7

    Related
    ENSP00000366666.3, ENST00000377447.7
    Conserved Domains (2) summary
    COG0523
    Location:42237
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_017014925.1XP_016870414.1  COBW domain-containing protein 1 isoform X8

RNA

  1. XR_001746352.1 RNA Sequence

  2. XR_001746353.1 RNA Sequence

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