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ADCY10 adenylate cyclase 10 [ Homo sapiens (human) ]

Gene ID: 55811, updated on 17-Jun-2019

Summary

Official Symbol
ADCY10provided by HGNC
Official Full Name
adenylate cyclase 10provided by HGNC
Primary source
HGNC:HGNC:21285
See related
Ensembl:ENSG00000143199 MIM:605205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
Summary
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
Expression
Restricted expression toward testis (RPKM 5.6) See more
Orthologs

Genomic context

See ADCY10 in Genome Data Viewer
Location:
1q24.2
Exon count:
36
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (167809080..167916389, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167778357..167883608, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon AGG) 2-1 Neighboring gene myelin protein zero like 1 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene microRNA 1255b-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
    Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
  • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'off' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase activity NAS
Non-traceable Author Statement
more info
PubMed 
bicarbonate binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cAMP biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to inorganic substance IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cilium movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basal part of cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylate cyclase type 10
Names
3',5'-cyclic AMP synthetase
AH-related protein
ATP pyrophosphate-lyase
adenylate cyclase 10, soluble
epididymis secretory sperm binding protein Li 7a
germ cell soluble adenylyl cyclase
testicular soluble adenylyl cyclase (SAC)
NP_001161221.1
NP_001284701.1
NP_060887.2
XP_005245387.1
XP_006711512.1
XP_011508062.1
XP_011508064.1
XP_011508065.1
XP_011508068.1
XP_016857267.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016139.1 RefSeqGene

    Range
    4990..109829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167749.3NP_001161221.1  adenylate cyclase type 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS53426.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000441992.1, ENST00000545172.5
    Conserved Domains (1) summary
    cd07302
    Location:139308
    CHD; cyclase homology domain
  2. NM_001297772.2NP_001284701.1  adenylate cyclase type 10 isoform 3

    See identical proteins and their annotated locations for NP_001284701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF299350, AF331033, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS72977.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000356822.1, ENST00000367848.1
    Conserved Domains (2) summary
    cd07302
    Location:200369
    CHD; cyclase homology domain
    cl11967
    Location:6122
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  3. NM_018417.6NP_060887.2  adenylate cyclase type 10 isoform 1

    See identical proteins and their annotated locations for NP_060887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS1265.1
    UniProtKB/Swiss-Prot
    Q96PN6
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Related
    ENSP00000356825.4, ENST00000367851.8
    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    167809080..167916389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509762.3XP_011508064.1  adenylate cyclase type 10 isoform X2

    Conserved Domains (3) summary
    cd07302
    Location:244413
    CHD; cyclase homology domain
    COG2114
    Location:42130
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    cl11967
    Location:43142
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  2. XM_011509763.3XP_011508065.1  adenylate cyclase type 10 isoform X3

    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  3. XM_006711449.4XP_006711512.1  adenylate cyclase type 10 isoform X4

    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  4. XM_011509760.3XP_011508062.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_011508062.1

    UniProtKB/Swiss-Prot
    Q96PN6
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  5. XM_005245330.5XP_005245387.1  adenylate cyclase type 10 isoform X6

    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485669
    AAA_16; AAA ATPase domain
  6. XM_017001778.2XP_016857267.1  adenylate cyclase type 10 isoform X5

  7. XM_011509766.3XP_011508068.1  adenylate cyclase type 10 isoform X7

    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485669
    AAA_16; AAA ATPase domain

RNA

  1. XR_921889.3 RNA Sequence

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