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ADCY10 adenylate cyclase 10 [ Homo sapiens (human) ]

Gene ID: 55811, updated on 17-Jun-2024

Summary

Official Symbol
ADCY10provided by HGNC
Official Full Name
adenylate cyclase 10provided by HGNC
Primary source
HGNC:HGNC:21285
See related
Ensembl:ENSG00000143199 MIM:605205; AllianceGenome:HGNC:21285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
Summary
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
Expression
Restricted expression toward testis (RPKM 5.6) See more
Orthologs
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Genomic context

See ADCY10 in Genome Data Viewer
Location:
1q24.2
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167809386..167914134, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167160872..167265599, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167778623..167883372, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167688821-167689320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167691547-167692047 Neighboring gene tRNA-Pro (anticodon AGG) 2-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167697263-167697762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2053 Neighboring gene myelin protein zero like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:167739237-167739808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167740743-167741244 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167761820-167761968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1538 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167830579-167831095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167831096-167831613 Neighboring gene Sharpr-MPRA regulatory region 4419 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167882400-167883076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167883077-167883753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1541 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167956130-167957329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2056 Neighboring gene microRNA 1255b-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables bicarbonate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NOT involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to inorganic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection retraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte end-foot IEA
Inferred from Electronic Annotation
more info
 
located_in basal part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in central region of growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylate cyclase type 10
Names
3',5'-cyclic AMP synthetase
AH-related protein
ATP pyrophosphate-lyase
adenylate cyclase 10, soluble
epididymis secretory sperm binding protein Li 7a
germ cell soluble adenylyl cyclase
testicular soluble adenylyl cyclase (SAC)
NP_001161221.1
NP_001284701.1
NP_060887.2
XP_005245387.1
XP_006711512.1
XP_011508062.1
XP_011508064.1
XP_011508065.1
XP_011508068.1
XP_016857267.1
XP_047281109.1
XP_054193620.1
XP_054193621.1
XP_054193622.1
XP_054193623.1
XP_054193624.1
XP_054193625.1
XP_054193626.1
XP_054193627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016139.2 RefSeqGene

    Range
    5000..109748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167749.3NP_001161221.1  adenylate cyclase type 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS53426.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000441992.1, ENST00000545172.5
    Conserved Domains (1) summary
    cd07302
    Location:139308
    CHD; cyclase homology domain
  2. NM_001297772.2NP_001284701.1  adenylate cyclase type 10 isoform 3

    See identical proteins and their annotated locations for NP_001284701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF299350, AF331033, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS72977.1
    UniProtKB/Swiss-Prot
    Q96PN6
    Related
    ENSP00000356822.1, ENST00000367848.1
    Conserved Domains (2) summary
    cd07302
    Location:200369
    CHD; cyclase homology domain
    cl11967
    Location:6122
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  3. NM_018417.6NP_060887.2  adenylate cyclase type 10 isoform 1

    See identical proteins and their annotated locations for NP_060887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF299350, AK302884, BC117366, DB063660, Z99943
    Consensus CDS
    CCDS1265.1
    UniProtKB/Swiss-Prot
    B4DZF0, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q96PN6, Q9NNX0
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Related
    ENSP00000356825.4, ENST00000367851.9
    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167809386..167914134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509762.4XP_011508064.1  adenylate cyclase type 10 isoform X2

    Conserved Domains (3) summary
    cd07302
    Location:244413
    CHD; cyclase homology domain
    COG2114
    Location:42130
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    cl11967
    Location:43142
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  2. XM_011509763.4XP_011508065.1  adenylate cyclase type 10 isoform X3

    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  3. XM_006711449.5XP_006711512.1  adenylate cyclase type 10 isoform X4

    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  4. XM_011509760.4XP_011508062.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_011508062.1

    UniProtKB/Swiss-Prot
    B4DZF0, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q96PN6, Q9NNX0
    UniProtKB/TrEMBL
    A0A0K0K1J8
    Conserved Domains (2) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
  5. XM_047425153.1XP_047281109.1  adenylate cyclase type 10 isoform X5

  6. XM_005245330.6XP_005245387.1  adenylate cyclase type 10 isoform X7

    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485669
    AAA_16; AAA ATPase domain
  7. XM_017001778.3XP_016857267.1  adenylate cyclase type 10 isoform X6

  8. XM_011509766.4XP_011508068.1  adenylate cyclase type 10 isoform X8

    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485669
    AAA_16; AAA ATPase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    167160872..167265599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337646.1XP_054193621.1  adenylate cyclase type 10 isoform X2

  2. XM_054337647.1XP_054193622.1  adenylate cyclase type 10 isoform X3

  3. XM_054337648.1XP_054193623.1  adenylate cyclase type 10 isoform X4

  4. XM_054337645.1XP_054193620.1  adenylate cyclase type 10 isoform X1

  5. XM_054337649.1XP_054193624.1  adenylate cyclase type 10 isoform X5

  6. XM_054337651.1XP_054193626.1  adenylate cyclase type 10 isoform X7

  7. XM_054337650.1XP_054193625.1  adenylate cyclase type 10 isoform X6

  8. XM_054337652.1XP_054193627.1  adenylate cyclase type 10 isoform X8