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IL26 interleukin 26 [ Homo sapiens (human) ]

Gene ID: 55801, updated on 8-Jul-2021

Summary

Official Symbol
IL26provided by HGNC
Official Full Name
interleukin 26provided by HGNC
Primary source
HGNC:HGNC:17119
See related
Ensembl:ENSG00000111536 MIM:605679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK155; IL-26
Summary
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL26 in Genome Data Viewer
Location:
12q15
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (68201349..68225810, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68595129..68619590, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene 39S ribosomal protein L21, mitochondrial pseudogene Neighboring gene interferon gamma Neighboring gene uncharacterized LOC105369818 Neighboring gene interleukin 22 Neighboring gene Mdm1 nuclear protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018402.2NP_060872.1  interleukin-26 precursor

    See identical proteins and their annotated locations for NP_060872.1

    Status: REVIEWED

    Source sequence(s)
    AC007458, AJ251549
    Consensus CDS
    CCDS8981.1
    UniProtKB/Swiss-Prot
    Q9NPH9
    Related
    ENSP00000229134.4, ENST00000229134.5
    Conserved Domains (1) summary
    cl02501
    Location:79164
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    68201349..68225810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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