Format

Send to:

Choose Destination

CMTR2 cap methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 55783, updated on 12-Oct-2019

Summary

Official Symbol
CMTR2provided by HGNC
Official Full Name
cap methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:25635
See related
Ensembl:ENSG00000180917 MIM:616190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFT; MTr2; HMTr2; FTSJD1
Expression
Ubiquitous expression in thyroid (RPKM 7.6), testis (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See CMTR2 in Genome Data Viewer
Location:
16q22.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (71281392..71290178, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71315292..71323509, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene VAC14 component of PIKFYVE complex Neighboring gene tRNA-Gly (anticodon GCC) 2-5 Neighboring gene RNA, U6atac small nuclear 25, pseudogene Neighboring gene HYDIN axonemal central pair apparatus protein Neighboring gene uncharacterized LOC102723786 Neighboring gene uncharacterized LOC102725168 Neighboring gene uncharacterized LOC105371332 Neighboring gene calbindin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystem (from WikiPathways)
    Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystemProtein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and not...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA (nucleoside-2'-O-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
cap1 mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cap2 mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cap2 mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Names
FtsJ methyltransferase domain containing 1
adrift homolog
cap2 2'O-ribose methyltransferase 2
ftsJ methyltransferase domain-containing protein 1
protein adrift homolog
NP_001093112.1
NP_001311303.1
NP_001311306.1
NP_001311307.1
NP_001311308.1
NP_060818.4
XP_011521530.1
XP_011521531.1
XP_016878933.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099642.2NP_001093112.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    See identical proteins and their annotated locations for NP_001093112.1

    Status: VALIDATED

    Source sequence(s)
    AA968997, AC106736, BC034468, DB240113
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  2. NM_001324374.2NP_001311303.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC106736, BC035005, BX648660
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Related
    ENSP00000337512.5, ENST00000338099.9
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  3. NM_001324377.2NP_001311306.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC106736, BC034468, BU429551, BX648660
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  4. NM_001324378.2NP_001311307.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC106736, BC034468, BX648660, DB094020
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  5. NM_001324379.2NP_001311308.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AC106736, BX648660
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  6. NM_018348.6NP_060818.4  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

    See identical proteins and their annotated locations for NP_060818.4

    Status: VALIDATED

    Source sequence(s)
    AA968997, AC106736, BC034468, BC035005, DB227997
    Consensus CDS
    CCDS10898.1
    UniProtKB/Swiss-Prot
    Q8IYT2
    Related
    ENSP00000411148.2, ENST00000434935.6
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    71281392..71290178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023444.1XP_016878933.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  2. XM_011523228.1XP_011521530.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011521530.1

    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase
  3. XM_011523229.1XP_011521531.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011521531.1

    UniProtKB/Swiss-Prot
    Q8IYT2
    Conserved Domains (1) summary
    pfam01728
    Location:114320
    FtsJ; FtsJ-like methyltransferase

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171813.1 Reference GRCh38.p13 PATCHES

    Range
    144072..152420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center