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DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 [ Homo sapiens (human) ]

Gene ID: 55735, updated on 5-Jul-2025
Official Symbol
DNAJC11provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C11provided by HGNC
Primary source
HGNC:HGNC:25570
See related
Ensembl:ENSG00000007923 MIM:614827; AllianceGenome:HGNC:25570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ126A5.1
Summary
Involved in cristae formation. Located in MICOS complex; SAM complex; and nuclear speck. Part of MIB complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in kidney (RPKM 23.0), colon (RPKM 15.3) and 25 other tissues See more
Orthologs
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See DNAJC11 in Genome Data Viewer
Location:
1p36.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6634170..6701816, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6159834..6227482, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6694230..6761876, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 86 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 88 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6664299-6664647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 171 Neighboring gene PHD finger protein 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 172 Neighboring gene THAP domain containing 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6706173-6706672 Neighboring gene Sharpr-MPRA regulatory region 8512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6774349-6775170 Neighboring gene long intergenic non-protein coding RNA 1672 Neighboring gene small nucleolar RNA U13

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ10737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cristae formation IEA
Inferred from Electronic Annotation
more info
 
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of MIB complex HDA PubMed 
part_of MICOS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAM complex HDA PubMed 
part_of SAM complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
dnaJ homolog subfamily C member 11
Names
DnaJ (Hsp40) homolog, subfamily C, member 11
novel DnaJ domain-containing protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018198.4NP_060668.2  dnaJ homolog subfamily C member 11

    See identical proteins and their annotated locations for NP_060668.2

    Status: VALIDATED

    Source sequence(s)
    AF306695, AL031447, AL159177, DB461237
    Consensus CDS
    CCDS87.1
    UniProtKB/Swiss-Prot
    Q4VWF5, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7, Q9NVH1
    UniProtKB/TrEMBL
    B4DPK2
    Related
    ENSP00000366800.5, ENST00000377577.10
    Conserved Domains (2) summary
    pfam00226
    Location:1479
    DnaJ; DnaJ domain
    pfam11875
    Location:417549
    DUF3395; Domain of unknown function (DUF3395)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6634170..6701816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424842.1XP_047280798.1  dnaJ homolog subfamily C member 11 isoform X1

    UniProtKB/TrEMBL
    B4DGD5, B4DPK2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    6159834..6227482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337587.1XP_054193562.1  dnaJ homolog subfamily C member 11 isoform X1

    UniProtKB/TrEMBL
    B4DGD5, B4DPK2