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LMBR1L limb development membrane protein 1 like [ Homo sapiens (human) ]

Gene ID: 55716, updated on 1-Jun-2020

Summary

Official Symbol
LMBR1Lprovided by HGNC
Official Full Name
limb development membrane protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:18268
See related
Ensembl:ENSG00000139636 MIM:610007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIMR
Expression
Broad expression in testis (RPKM 15.2), endometrium (RPKM 7.0) and 24 other tissues See more
Orthologs

Genomic context

See LMBR1L in Genome Data Viewer
Location:
12q13.12
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49096551..49110900, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49490334..49504683, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RHEB like 1 Neighboring gene uncharacterized LOC105369759 Neighboring gene GATA motif-containing MPRA enhancer 293 Neighboring gene desert hedgehog signaling molecule Neighboring gene Sharpr-MPRA regulatory region 3992 Neighboring gene uncharacterized LOC105369760 Neighboring gene tubulin alpha 1b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10494, FLJ36251, KIAA1174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein LMBR1L
Names
limb region 1 homolog-like
limb region 1 protein homolog-like
limb region 1-like protein -like
lipocalin-1 interacting membrane receptor
lipocalin-interacting membrane receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300750.1NP_001287679.1  protein LMBR1L isoform 2

    See identical proteins and their annotated locations for NP_001287679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate AUG to encode an isoform (2) that has a distinct N-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AC011603, AK001356, AK001651, BC015015, DA012883
    UniProtKB/Swiss-Prot
    Q6UX01
    UniProtKB/TrEMBL
    A0A024R0Z6
    Conserved Domains (1) summary
    pfam04791
    Location:54445
    LMBR1; LMBR1-like membrane protein
  2. NM_001300751.1NP_001287680.1  protein LMBR1L isoform 3

    See identical proteins and their annotated locations for NP_001287680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC011603, AK001651, BC015015, DA012883
    Consensus CDS
    CCDS73466.1
    UniProtKB/Swiss-Prot
    Q6UX01
    UniProtKB/TrEMBL
    A0A0S2Z6E3
    Related
    ENSP00000447329.1, ENST00000547382.5
    Conserved Domains (1) summary
    pfam04791
    Location:21435
    LMBR1; LMBR1-like membrane protein
  3. NM_001352161.1NP_001339090.1  protein LMBR1L isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:21462
    LMBR1; LMBR1-like membrane protein
  4. NM_001352162.1NP_001339091.1  protein LMBR1L isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:47397
    LMBR1; LMBR1-like membrane protein
  5. NM_001352163.1NP_001339092.1  protein LMBR1L isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:1335
    LMBR1; LMBR1-like membrane protein
  6. NM_001352164.1NP_001339093.1  protein LMBR1L isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:1268
    LMBR1; LMBR1-like membrane protein
  7. NM_001352165.1NP_001339094.1  protein LMBR1L isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform 8.
    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:1328
    LMBR1; LMBR1-like membrane protein
  8. NM_001352166.1NP_001339095.1  protein LMBR1L isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform 8.
    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:1328
    LMBR1; LMBR1-like membrane protein
  9. NM_001352167.1NP_001339096.1  protein LMBR1L isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 9.
    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:61247
    LMBR1; LMBR1-like membrane protein
  10. NM_001352168.1NP_001339097.1  protein LMBR1L isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 9.
    Source sequence(s)
    AC011603
    Conserved Domains (1) summary
    pfam04791
    Location:61247
    LMBR1; LMBR1-like membrane protein
  11. NM_018113.3NP_060583.2  protein LMBR1L isoform 1

    See identical proteins and their annotated locations for NP_060583.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011603, AK001651, BC015015, DA012883
    Consensus CDS
    CCDS8780.2
    UniProtKB/Swiss-Prot
    Q6UX01
    UniProtKB/TrEMBL
    A0A024R0Y9
    Related
    ENSP00000267102.8, ENST00000267102.12
    Conserved Domains (1) summary
    pfam04791
    Location:21455
    LMBR1; LMBR1-like membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49096551..49110900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449053.1XP_024304821.1  protein LMBR1L isoform X7

    Conserved Domains (1) summary
    pfam04791
    Location:21395
    LMBR1; LMBR1-like membrane protein
  2. XM_024449052.1XP_024304820.1  protein LMBR1L isoform X5

    Conserved Domains (1) summary
    pfam04791
    Location:21447
    LMBR1; LMBR1-like membrane protein
  3. XM_017019627.2XP_016875116.1  protein LMBR1L isoform X6

  4. XM_024449049.1XP_024304817.1  protein LMBR1L isoform X2

    Conserved Domains (1) summary
    pfam04791
    Location:54482
    LMBR1; LMBR1-like membrane protein
  5. XM_017019626.2XP_016875115.1  protein LMBR1L isoform X4

    UniProtKB/TrEMBL
    A0A024R0Z6
    Conserved Domains (1) summary
    pfam04791
    Location:54445
    LMBR1; LMBR1-like membrane protein
  6. XM_024449048.1XP_024304816.1  protein LMBR1L isoform X2

    Conserved Domains (1) summary
    pfam04791
    Location:54482
    LMBR1; LMBR1-like membrane protein
  7. XM_017019630.2XP_016875119.1  protein LMBR1L isoform X9

    Conserved Domains (1) summary
    pfam04791
    Location:61247
    LMBR1; LMBR1-like membrane protein
  8. XM_024449051.1XP_024304819.1  protein LMBR1L isoform X3

    Conserved Domains (1) summary
    pfam04791
    Location:21467
    LMBR1; LMBR1-like membrane protein
  9. XM_024449047.1XP_024304815.1  protein LMBR1L isoform X1

    Conserved Domains (1) summary
    pfam04791
    Location:21487
    LMBR1; LMBR1-like membrane protein
  10. XM_017019631.2XP_016875120.1  protein LMBR1L isoform X10

  11. XM_024449050.1XP_024304818.1  protein LMBR1L isoform X2

    Conserved Domains (1) summary
    pfam04791
    Location:54482
    LMBR1; LMBR1-like membrane protein
  12. XM_024449054.1XP_024304822.1  protein LMBR1L isoform X8

    Conserved Domains (1) summary
    pfam04791
    Location:21354
    LMBR1; LMBR1-like membrane protein

RNA

  1. XR_001748803.2 RNA Sequence

  2. XR_001748802.1 RNA Sequence

  3. XR_245944.3 RNA Sequence

  4. XR_002957350.1 RNA Sequence

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