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DOK4 docking protein 4 [ Homo sapiens (human) ]

Gene ID: 55715, updated on 13-Mar-2020

Summary

Official Symbol
DOK4provided by HGNC
Official Full Name
docking protein 4provided by HGNC
Primary source
HGNC:HGNC:19868
See related
Ensembl:ENSG00000125170 MIM:608333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRS5; IRS-5
Expression
Ubiquitous expression in colon (RPKM 23.2), small intestine (RPKM 21.5) and 25 other tissues See more
Orthologs

Genomic context

See DOK4 in Genome Data Viewer
Location:
16q21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57471922..57487139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57505870..57520385, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene coenzyme Q9 Neighboring gene RNA polymerase II subunit C Neighboring gene coiled-coil domain containing 102A Neighboring gene adhesion G protein-coupled receptor G5 Neighboring gene uncharacterized LOC105371291 Neighboring gene uncharacterized LOC107984889

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
docking protein 4
Names
downstream of tyrosine kinase 4
insulin receptor substrate 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330556.2NP_001317485.1  docking protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Consensus CDS
    CCDS81986.1
    UniProtKB/TrEMBL
    H3BQ19
    Related
    ENSP00000455566.1, ENST00000566936.5
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  2. NM_001369618.1NP_001356547.1  docking protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  3. NM_001369619.1NP_001356548.1  docking protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  4. NM_001369620.1NP_001356549.1  docking protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  5. NM_001369621.1NP_001356550.1  docking protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Related
    ENSP00000455128.1, ENST00000569548.5
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  6. NM_018110.5NP_060580.2  docking protein 4 isoform 1

    See identical proteins and their annotated locations for NP_060580.2

    Status: VALIDATED

    Source sequence(s)
    AC009052
    Consensus CDS
    CCDS10783.1
    UniProtKB/Swiss-Prot
    Q8TEW6
    UniProtKB/TrEMBL
    A0A024R6S2
    Related
    ENSP00000344277.4, ENST00000340099.9
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57471922..57487139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450348.1XP_024306116.1  docking protein 4 isoform X1

    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  2. XM_024450347.1XP_024306115.1  docking protein 4 isoform X1

    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
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