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DENND4C DENN domain containing 4C [ Homo sapiens (human) ]

Gene ID: 55667, updated on 3-Nov-2024

Summary

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Official Symbol
DENND4Cprovided by HGNC
Official Full Name
DENN domain containing 4Cprovided by HGNC
Primary source
HGNC:HGNC:26079
See related
Ensembl:ENSG00000137145 AllianceGenome:HGNC:26079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf55; C9orf55B; RAB10GEF; bA513M16.3
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum (RPKM 11.5), skin (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

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See DENND4C in Genome Data Viewer
Location:
9p22.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (19230513..19374281)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (19243303..19387084)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (19230511..19374279)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19126736-19127246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19127247-19127756 Neighboring gene perilipin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr9.246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28219 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19186502-19187002 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19202444-19202962 Neighboring gene ribosomal protein S6 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230483-19230989 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230990-19231495 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:19233697-19233870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19250753-19251617 Neighboring gene uncharacterized LOC124902350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:19379549-19380748 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 3 Neighboring gene ribosomal protein S6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells. Yang B, et al. Chem Biol Interact, 2024 Mar 1. PMID 38412628
  2. Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. Ren S, et al. J Exp Clin Cancer Res, 2019 Sep 5. PMID 31488193, Free PMC Article
  3. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. Semova N, et al. Genomics, 2003 Sep. PMID 12906859
  4. circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c. Liu S, et al. Ann Med, 2023 Dec. PMID 36896567, Free PMC Article
  5. Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis. Zhang ZJ, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196590

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.
    Title: Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.
  2. circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
    Title: circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
  3. Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.
    Title: Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.
  4. circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c.
    Title: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia.
  5. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
    Title: Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20686, DKFZp686I09113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in insulin-responsive compartment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of retromer complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 4C
Names
DENN/MADD domain containing 4A pseudogene
DENN/MADD domain containing 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330640.2 → NP_001317569.1  DENN domain-containing protein 4C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Consensus CDS
    CCDS83349.1
    UniProtKB/Swiss-Prot
    Q5VZ89
    Related
    ENSP00000473469.1, ENST00000434457.7
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  2. NM_001386026.2 → NP_001372955.1  DENN domain-containing protein 4C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  3. NM_001386030.1 → NP_001372959.1  DENN domain-containing protein 4C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:524 → 597
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:785 → 814
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 457
    DENN; DENN (AEX-3) domain

  4. NM_001386031.1 → NP_001372960.1  DENN domain-containing protein 4C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (1) summary
    sd00004
    Location:255 → 284
    PPR; PPR repeat [structural motif]

  5. NM_001386032.1 → NP_001372961.1  DENN domain-containing protein 4C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (2) summary
    smart00801
    Location:57 → 130
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:318 → 347
    PPR; PPR repeat [structural motif]

  6. NM_001386034.1 → NP_001372963.1  DENN domain-containing protein 4C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (2) summary
    smart00801
    Location:57 → 130
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:318 → 347
    PPR; PPR repeat [structural motif]

  7. NM_001386035.1 → NP_001372964.1  DENN domain-containing protein 4C isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (3) summary
    smart00801
    Location:207 → 280
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:468 → 497
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:1 → 140
    DENN; DENN (AEX-3) domain

  8. NM_001386036.1 → NP_001372965.1  DENN domain-containing protein 4C isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (2) summary
    smart00801
    Location:165 → 238
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:426 → 455
    PPR; PPR repeat [structural motif]

  9. NM_001386037.1 → NP_001372966.1  DENN domain-containing protein 4C isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:752 → 780
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  10. NM_001386038.1 → NP_001372967.1  DENN domain-containing protein 4C isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  11. NM_001386039.1 → NP_001372968.1  DENN domain-containing protein 4C isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (2) summary
    smart00801
    Location:57 → 130
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:318 → 347
    PPR; PPR repeat [structural motif]

  12. NM_001386040.1 → NP_001372969.1  DENN domain-containing protein 4C isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  13. NM_001386041.1 → NP_001372970.1  DENN domain-containing protein 4C isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:752 → 780
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  14. NM_001386042.1 → NP_001372971.1  DENN domain-containing protein 4C isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  15. NM_001386043.1 → NP_001372972.1  DENN domain-containing protein 4C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:323 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:584 → 613
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:73 → 256
    DENN; DENN (AEX-3) domain
    cl04085
    Location:1 → 40
    uDENN; uDENN domain

  16. NM_001386044.1 → NP_001372973.1  DENN domain-containing protein 4C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:323 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:584 → 613
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:73 → 256
    DENN; DENN (AEX-3) domain
    cl04085
    Location:1 → 40
    uDENN; uDENN domain

  17. NM_001386045.1 → NP_001372974.1  DENN domain-containing protein 4C isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  18. NM_001386046.1 → NP_001372975.1  DENN domain-containing protein 4C isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:752 → 780
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  19. NM_001386047.1 → NP_001372976.1  DENN domain-containing protein 4C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Consensus CDS
    CCDS83349.1
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  20. NM_001386048.1 → NP_001372977.1  DENN domain-containing protein 4C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834
    Conserved Domains (4) summary
    smart00801
    Location:323 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:584 → 613
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:73 → 256
    DENN; DENN (AEX-3) domain
    cl04085
    Location:1 → 40
    uDENN; uDENN domain

  21. NM_017925.7 → NP_060395.5  DENN domain-containing protein 4C isoform 1

    See identical proteins and their annotated locations for NP_060395.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK125842, AL161909, AL391834, AW271839, CN427691, DA517991, DV080472, HY106197
    Consensus CDS
    CCDS6491.3
    UniProtKB/Swiss-Prot
    A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2
    Related
    ENSP00000473565.1, ENST00000602925.5
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:310 → 492
    DENN; DENN (AEX-3) domain

RNA

  1. NR_073201.4 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons, and includes two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL161909, AL391834, AW271839, BC144485, DA517991, DV080472, HY106197

  2. NR_169842.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  3. NR_169843.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  4. NR_169844.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  5. NR_169845.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  6. NR_169846.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  7. NR_169847.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  8. NR_169848.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  9. NR_169849.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  10. NR_169850.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  11. NR_169851.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  12. NR_169852.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  13. NR_169853.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

  14. NR_169854.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161909, AL391834

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    19230513..19374281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423585.1 → XP_047279541.1  DENN domain-containing protein 4C isoform X2

  2. XM_047423584.1 → XP_047279540.1  DENN domain-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2

  3. XM_047423586.1 → XP_047279542.1  DENN domain-containing protein 4C isoform X3

  4. XM_011517959.4 → XP_011516261.1  DENN domain-containing protein 4C isoform X4

    Conserved Domains (5) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain
    pfam13041
    Location:819 → 858
    PPR_2; PPR repeat family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    19243303..19387084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363271.1 → XP_054219246.1  DENN domain-containing protein 4C isoform X2

  2. XM_054363270.1 → XP_054219245.1  DENN domain-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2

  3. XM_054363272.1 → XP_054219247.1  DENN domain-containing protein 4C isoform X3

  4. XM_054363273.1 → XP_054219248.1  DENN domain-containing protein 4C isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_023879.1: Suppressed sequence

    Description
    NG_023879.1: This RefSeq was suppressed because review of this locus determined that it is not a non-transcribed pseudogene; it represents a region of the DENND4C (GeneID: 55667) gene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZ89.3 GenPept UniProtKB/Swiss-Prot:Q5VZ89

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