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SYBU syntabulin [ Homo sapiens (human) ]

Gene ID: 55638, updated on 1-Jun-2020

Summary

Official Symbol
SYBUprovided by HGNC
Official Full Name
syntabulinprovided by HGNC
Primary source
HGNC:HGNC:26011
See related
Ensembl:ENSG00000147642 MIM:611568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCSYN; SNPHL; GOLSYN
Summary
Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in brain (RPKM 10.5), fat (RPKM 7.9) and 21 other tissues See more
Orthologs

Genomic context

See SYBU in Genome Data Viewer
Location:
8q23.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (109573978..109691791, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110586405..110704020, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PKHD1 like 1 Neighboring gene mitogen-activated protein kinase 6 pseudogene 5 Neighboring gene estrogen receptor binding site associated antigen 9 Neighboring gene uncharacterized LOC100132813 Neighboring gene SMG5 nonsense mediated mRNA decay factor pseudogene Neighboring gene ribosomal protein L18 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20366, KIAA1472

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinesin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin-1 binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterograde neuronal dense core vesicle transport IEA
Inferred from Electronic Annotation
more info
 
axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic activity IEA
Inferred from Electronic Annotation
more info
 
synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dense body IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
syntabulin
Names
GOLSYN A protein
GOLSYN B protein
GOLSYN C protein
Golgi-localized protein
golgi-localized syntaphilin-related protein
implicated in syntaxin trafficking in neurons
microtubule-associated protein
syntabulin (syntaxin-interacting)
syntaxin-1-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099743.2NP_001093213.1  syntabulin isoform b

    See identical proteins and their annotated locations for NP_001093213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 7-11 encode the same isoform.
    Source sequence(s)
    AB195676, AC079061, BU607867, DA155137
    Consensus CDS
    CCDS43763.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Conserved Domains (1) summary
    pfam15290
    Location:234423
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  2. NM_001099744.1NP_001093214.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-6 encode the same isoform.
    Source sequence(s)
    AB195676, BG702715, BU607867, DA803330
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000407118.1, ENST00000422135.5
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  3. NM_001099745.2NP_001093215.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same isoform (a).
    Source sequence(s)
    AB195676, AC079061, BU607867, DC350594
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000434679.1, ENST00000533171.5
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  4. NM_001099746.1NP_001093216.1  syntabulin isoform d

    See identical proteins and their annotated locations for NP_001093216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 13-15 encode the same isoform.
    Source sequence(s)
    AB195676, BU607867, DB155885, DC350594
    Consensus CDS
    CCDS55271.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000386196.3, ENST00000408889.7
    Conserved Domains (1) summary
    pfam15290
    Location:116305
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  5. NM_001099747.2NP_001093217.1  syntabulin isoform b

    See identical proteins and their annotated locations for NP_001093217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 7-11 encode the same isoform.
    Source sequence(s)
    AB195677, AC079061, BU607867
    Consensus CDS
    CCDS43763.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000414748.2, ENST00000446070.6
    Conserved Domains (1) summary
    pfam15290
    Location:234423
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  6. NM_001099748.1NP_001093218.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same isoform (a).
    Source sequence(s)
    AB195677, BU607867, DA530258, DN993094
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000386154.2, ENST00000408908.6
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  7. NM_001099749.2NP_001093219.1  syntabulin isoform d

    See identical proteins and their annotated locations for NP_001093219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 13-15 encode the same isoform.
    Source sequence(s)
    AB195678, AC079061, BU607867
    Consensus CDS
    CCDS55271.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000436041.1, ENST00000528331.5
    Conserved Domains (1) summary
    pfam15290
    Location:116305
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  8. NM_001099750.1NP_001093220.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same isoform (a).
    Source sequence(s)
    AB195676, BU607867, CA395128, DA530258
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000403544.1, ENST00000433638.1
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  9. NM_001099751.1NP_001093221.1  syntabulin isoform b

    See identical proteins and their annotated locations for NP_001093221.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 7-11 encode the same isoform.
    Source sequence(s)
    AB195677, AK055246, BU607867, DA787454
    Consensus CDS
    CCDS43763.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000432501.1, ENST00000528647.5
    Conserved Domains (1) summary
    pfam15290
    Location:234423
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  10. NM_001099752.1NP_001093222.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same isoform (a).
    Source sequence(s)
    AB195677, AK055246, BU607867, DA787454
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000404369.1, ENST00000440310.5
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  11. NM_001099753.2NP_001093223.1  syntabulin isoform b

    See identical proteins and their annotated locations for NP_001093223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 7-11 encode the same isoform.
    Source sequence(s)
    AB195676, AC079061, BU607867, DA773983, DB127917
    Consensus CDS
    CCDS43763.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Conserved Domains (1) summary
    pfam15290
    Location:234423
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  12. NM_001099754.2NP_001093224.1  syntabulin isoform a

    See identical proteins and their annotated locations for NP_001093224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same isoform (a).
    Source sequence(s)
    AB195676, AC079061, AK096558, BU607867, DB127917
    Consensus CDS
    CCDS47912.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000276646.9, ENST00000276646.14
    Conserved Domains (1) summary
    pfam15290
    Location:235424
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  13. NM_001099755.2NP_001093225.1  syntabulin isoform d

    See identical proteins and their annotated locations for NP_001093225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 13-15 encode the same isoform.
    Source sequence(s)
    AB195676, AC079061, AK090559, BU607867, DB127917
    Consensus CDS
    CCDS55271.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000432962.1, ENST00000533065.5
    Conserved Domains (1) summary
    pfam15290
    Location:116305
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  14. NM_001099756.1NP_001093226.1  syntabulin isoform c

    See identical proteins and their annotated locations for NP_001093226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AB195679, BU607867
    Consensus CDS
    CCDS43764.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000382019.3, ENST00000399066.7
    Conserved Domains (1) summary
    pfam15290
    Location:232421
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  15. NM_001330596.2NP_001317525.1  syntabulin isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (e) is shorter than and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA255630, AK297182, AL834406, DC351469
    Consensus CDS
    CCDS83315.1
    UniProtKB/Swiss-Prot
    Q9NX95
    UniProtKB/TrEMBL
    B7Z4D2
    Related
    ENSP00000433941.1, ENST00000529690.5
  16. NM_001363032.2NP_001349961.1  syntabulin isoform f

    Status: VALIDATED

    Source sequence(s)
    AB195676, AC079061, BU607867, DA309225
    Related
    ENSP00000434871.1, ENST00000529175.5
    Conserved Domains (1) summary
    pfam15290
    Location:72259
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  17. NM_017786.6NP_060256.3  syntabulin isoform b

    See identical proteins and their annotated locations for NP_060256.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 7-11 encode the same isoform.
    Source sequence(s)
    AB195676, AC079061, BU607867
    Consensus CDS
    CCDS43763.1
    UniProtKB/Swiss-Prot
    Q9NX95
    Related
    ENSP00000433446.1, ENST00000533895.5
    Conserved Domains (1) summary
    pfam15290
    Location:234423
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    109573978..109691791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013615.1XP_016869104.1  syntabulin isoform X1

    UniProtKB/Swiss-Prot
    Q9NX95
    Conserved Domains (1) summary
    pfam15290
    Location:116305
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  2. XM_017013614.1XP_016869103.1  syntabulin isoform X1

    UniProtKB/Swiss-Prot
    Q9NX95
    Conserved Domains (1) summary
    pfam15290
    Location:116305
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  3. XM_011517154.2XP_011515456.1  syntabulin isoform X3

    Conserved Domains (1) summary
    pfam15290
    Location:68257
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
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