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DEPDC1 DEP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55635, updated on 13-Mar-2020

Summary

Official Symbol
DEPDC1provided by HGNC
Official Full Name
DEP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:22949
See related
Ensembl:ENSG00000024526 MIM:612002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEP.8; SDP35; DEPDC1A; DEPDC1-V2
Expression
Biased expression in testis (RPKM 5.4), lymph node (RPKM 3.0) and 13 other tissues See more
Orthologs

Genomic context

See DEPDC1 in Genome Data Viewer
Location:
1p31.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (68474152..68497082, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (68939835..68962799, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongin C pseudogene 18 Neighboring gene retinoid isomerohydrolase RPE65 Neighboring gene DEPDC1 antisense RNA 1 Neighboring gene thioredoxin pseudogene 2 Neighboring gene uncharacterized LOC107984967

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ20354, 5830484J08Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DEP domain-containing protein 1A
Names
cell cycle control protein SDP35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114120.3NP_001107592.1  DEP domain-containing protein 1A isoform a

    See identical proteins and their annotated locations for NP_001107592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB281187, BU588593, DB147703
    Consensus CDS
    CCDS44159.1
    UniProtKB/Swiss-Prot
    Q5TB30
    Related
    ENSP00000412292.2, ENST00000456315.7
    Conserved Domains (3) summary
    cd04405
    Location:181308
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cl02442
    Location:15106
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    cl02570
    Location:584690
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  2. NM_017779.6NP_060249.2  DEP domain-containing protein 1A isoform b

    See identical proteins and their annotated locations for NP_060249.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AB281274, BU588593, DB147703
    Consensus CDS
    CCDS644.1
    UniProtKB/Swiss-Prot
    Q5TB30
    Related
    ENSP00000360005.5, ENST00000370966.9
    Conserved Domains (2) summary
    cd04405
    Location:181406
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cl02442
    Location:15106
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    68474152..68497082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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