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TASP1 taspase 1 [ Homo sapiens (human) ]

Gene ID: 55617, updated on 8-Jul-2018
Official Symbol
TASP1provided by HGNC
Official Full Name
taspase 1provided by HGNC
Primary source
HGNC:HGNC:15859
See related
Ensembl:ENSG00000089123 MIM:608270; Vega:OTTHUMG00000031904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf13; dJ585I14.2
Summary
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.9), testis (RPKM 2.2) and 25 other tissues See more
Orthologs
See TASP1 in Genome Data Viewer
Location:
20p12.1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (13104760..13638936, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (13370036..13619583, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1722 Neighboring gene long intergenic non-protein coding RNA 1723 Neighboring gene coiled-coil domain containing 84 pseudogene Neighboring gene serine palmitoyltransferase long chain base subunit 3 Neighboring gene uncharacterized LOC105372539 Neighboring gene ISM1 antisense RNA 1 Neighboring gene isthmin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 2 Neighboring gene mitochondrial ribosomal protein S36 pseudogene 6 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20212, MGC39159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-aspartyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
threonine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
threonine aspartase 1
NP_001310531.1
NP_001310532.1
NP_001310533.1
NP_060184.2
XP_011527594.1
XP_011527596.1
XP_016883416.1
XP_016883417.1
XP_016883418.1
XP_016883419.1
XP_016883420.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323602.1NP_001310531.1  threonine aspartase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, AL601028, CA418131
    Conserved Domains (1) summary
    cd04514
    Location:42285
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  2. NM_001323603.1NP_001310532.1  threonine aspartase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, CA418131
    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  3. NM_001323604.1NP_001310533.1  threonine aspartase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, CA418131
    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  4. NM_017714.2NP_060184.2  threonine aspartase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_060184.2

    Status: REVIEWED

    Source sequence(s)
    AL601028, BC025266, CA418131
    Consensus CDS
    CCDS13116.1
    UniProtKB/Swiss-Prot
    Q9H6P5
    Related
    ENSP00000338624.4, OTTHUMP00000030296, ENST00000337743.8, OTTHUMT00000078041
    Conserved Domains (1) summary
    cd04514
    Location:42416
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

RNA

  1. NR_136628.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, CA418131
  2. NR_136629.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, AL601028, CA418131
  3. NR_136630.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, AL601028, CA418131
  4. NR_136631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121754, AL121782, AL601028, CA418131

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    13104760..13638936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027930.1XP_016883419.1  threonine aspartase 1 isoform X3

  2. XM_011529292.1XP_011527594.1  threonine aspartase 1 isoform X1

    See identical proteins and their annotated locations for XP_011527594.1

    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  3. XM_011529294.1XP_011527596.1  threonine aspartase 1 isoform X1

    See identical proteins and their annotated locations for XP_011527596.1

    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  4. XM_017027927.1XP_016883416.1  threonine aspartase 1 isoform X1

    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  5. XM_017027928.1XP_016883417.1  threonine aspartase 1 isoform X1

    Conserved Domains (1) summary
    cd04514
    Location:2314
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
  6. XM_017027929.2XP_016883418.1  threonine aspartase 1 isoform X2

  7. XM_017027931.2XP_016883420.1  threonine aspartase 1 isoform X4

RNA

  1. XR_001754319.2 RNA Sequence

  2. XR_430268.2 RNA Sequence

    Related
    ENST00000480436.5
  3. XR_001754321.2 RNA Sequence

  4. XR_001754320.2 RNA Sequence

  5. XR_001754323.1 RNA Sequence

  6. XR_001754325.1 RNA Sequence

  7. XR_001754324.1 RNA Sequence

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