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ANKRD10 ankyrin repeat domain 10 [ Homo sapiens (human) ]

Gene ID: 55608, updated on 21-Dec-2019

Summary

Official Symbol
ANKRD10provided by HGNC
Official Full Name
ankyrin repeat domain 10provided by HGNC
Primary source
HGNC:HGNC:20265
See related
Ensembl:ENSG00000088448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 23.6) and 25 other tissues See more
Orthologs

Genomic context

See ANKRD10 in Genome Data Viewer
Location:
13q34
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (110878540..110915071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111530887..111567454, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370363 Neighboring gene p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript Neighboring gene uncharacterized LOC105370364 Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr13.1281

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20093, DKFZp686B07190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286721.2NP_001273650.1  ankyrin repeat domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001273650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and contains multiple differences in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL442128
    Consensus CDS
    CCDS66580.1
    UniProtKB/Swiss-Prot
    Q9NXR5
    Related
    ENSP00000312534.4, ENST00000310847.8
    Conserved Domains (2) summary
    cd00204
    Location:25145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]
  2. NM_017664.4NP_060134.2  ankyrin repeat domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_060134.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK000100, AK094222, AL157875
    Consensus CDS
    CCDS9520.1
    UniProtKB/Swiss-Prot
    Q9NXR5
    UniProtKB/TrEMBL
    A0A024RE01
    Related
    ENSP00000267339.2, ENST00000267339.6
    Conserved Domains (5) summary
    COG0666
    Location:111217
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:57178
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:63155
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2578
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]

RNA

  1. NR_104586.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL442128
  2. NR_104587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL157875, BX354283, DA961131

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    110878540..110915071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449380.1XP_024305148.1  ankyrin repeat domain-containing protein 10 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:57178
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:2574
    Ank_4; Ankyrin repeats (many copies)
  2. XM_024449382.1XP_024305150.1  ankyrin repeat domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    cd00204
    Location:25145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]
  3. XM_024449381.1XP_024305149.1  ankyrin repeat domain-containing protein 10 isoform X2

    Related
    ENSP00000431927.1, ENST00000465753.1
    Conserved Domains (2) summary
    cd00204
    Location:25145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]
  4. XM_024449383.1XP_024305151.1  ankyrin repeat domain-containing protein 10 isoform X4

    Conserved Domains (2) summary
    cd00204
    Location:25145
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5789
    ANK; ANK repeat [structural motif]

RNA

  1. XR_002957458.1 RNA Sequence

  2. XR_002957459.1 RNA Sequence

  3. XR_002957460.1 RNA Sequence

  4. XR_002957468.1 RNA Sequence

  5. XR_002957467.1 RNA Sequence

  6. XR_002957464.1 RNA Sequence

  7. XR_002957466.1 RNA Sequence

  8. XR_002957465.1 RNA Sequence

  9. XR_002957461.1 RNA Sequence

  10. XR_002957463.1 RNA Sequence

  11. XR_002957462.1 RNA Sequence

  12. XR_002957469.1 RNA Sequence

  13. XR_002957471.1 RNA Sequence

  14. XR_002957470.1 RNA Sequence

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