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KIF21A kinesin family member 21A [ Homo sapiens (human) ]

Gene ID: 55605, updated on 5-Aug-2018

Summary

Official Symbol
KIF21Aprovided by HGNC
Official Full Name
kinesin family member 21Aprovided by HGNC
Primary source
HGNC:HGNC:19349
See related
Ensembl:ENSG00000139116 MIM:608283; Vega:OTTHUMG00000169335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEOM1; CFEOM1; FEOM3A
Summary
This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Expression
Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues See more
Orthologs

Genomic context

See KIF21A in Genome Data Viewer
Location:
12q12
Exon count:
38
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (39293228..39443390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (39687030..39837192, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984484 Neighboring gene long intergenic non-protein coding RNA 2406 Neighboring gene uncharacterized LOC101927019 Neighboring gene ribosomal protein L7a pseudogene Neighboring gene ATP binding cassette subfamily D member 2 Neighboring gene chromosome 12 open reading frame 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20052, KIAA1708, DKFZp779C159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kinesin-like protein KIF21A
Names
kinesin-like protein KIF2
renal carcinoma antigen NY-REN-62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017067.1 RefSeqGene

    Range
    5001..155163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173463.1NP_001166934.1  kinesin-like protein KIF21A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB051495, AB290166, AC084373, AW131223, BC136414
    Consensus CDS
    CCDS53775.1
    UniProtKB/Swiss-Prot
    Q7Z4S6
    Related
    ENSP00000445606.2, OTTHUMP00000240842, ENST00000544797.6, OTTHUMT00000403580
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13081618
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:655791
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13021615
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:649786
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13531412
    7WD40; WD40 repeat [structural motif]
  2. NM_001173464.1NP_001166935.1  kinesin-like protein KIF21A isoform 1

    See identical proteins and their annotated locations for NP_001166935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB051495, AB290166, AW131223, AY368076
    Consensus CDS
    CCDS53776.1
    UniProtKB/Swiss-Prot
    Q7Z4S6
    Related
    ENSP00000354878.5, OTTHUMP00000240843, ENST00000361418.9, OTTHUMT00000403581
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13451655
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13391652
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13901449
    7WD40; WD40 repeat [structural motif]
  3. NM_001173465.1NP_001166936.1  kinesin-like protein KIF21A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AB051495, AB290166, AC084373, AC090668, AM177179, AW131223, BC041430, DA293947
    Consensus CDS
    CCDS53774.1
    UniProtKB/Swiss-Prot
    Q7Z4S6
    Related
    ENSP00000438075.2, OTTHUMP00000240844, ENST00000541463.6, OTTHUMT00000403582
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12921602
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:655791
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:12861599
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:649786
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13371396
    7WD40; WD40 repeat [structural motif]
  4. NM_017641.3NP_060111.2  kinesin-like protein KIF21A isoform 2

    See identical proteins and their annotated locations for NP_060111.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB290166, AC084373, AW131223
    Consensus CDS
    CCDS31773.1
    UniProtKB/Swiss-Prot
    Q7Z4S6
    Related
    ENSP00000354851.3, OTTHUMP00000240839, ENST00000361961.7, OTTHUMT00000403577
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13321642
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:655791
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13261639
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:649786
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13771436
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    39293228..39443390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019609.2XP_016875098.1  kinesin-like protein KIF21A isoform X14

  2. XM_006719493.3XP_006719556.1  kinesin-like protein KIF21A isoform X7

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13261636
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:655791
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13201633
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:649786
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13711430
    7WD40; WD40 repeat [structural motif]
  3. XM_017019611.2XP_016875100.1  kinesin-like protein KIF21A isoform X16

  4. XM_017019608.2XP_016875097.1  kinesin-like protein KIF21A isoform X9

  5. XM_017019607.2XP_016875096.1  kinesin-like protein KIF21A isoform X5

  6. XM_005269010.3XP_005269067.1  kinesin-like protein KIF21A isoform X4

    Related
    ENSP00000490369.1, OTTHUMP00000281790, ENST00000636569.1
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13331643
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:655791
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13271640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:649786
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13781437
    7WD40; WD40 repeat [structural motif]
  7. XM_011538556.3XP_011536858.1  kinesin-like protein KIF21A isoform X8

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13231633
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13171630
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13681427
    7WD40; WD40 repeat [structural motif]
  8. XM_017019610.2XP_016875099.1  kinesin-like protein KIF21A isoform X15

  9. XM_005269009.3XP_005269066.1  kinesin-like protein KIF21A isoform X3

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13391649
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13331646
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13841443
    7WD40; WD40 repeat [structural motif]
  10. XM_005269014.3XP_005269071.1  kinesin-like protein KIF21A isoform X13

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12851595
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:12791592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13301389
    7WD40; WD40 repeat [structural motif]
  11. XM_005269013.3XP_005269070.1  kinesin-like protein KIF21A isoform X12

    UniProtKB/Swiss-Prot
    Q7Z4S6
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12981608
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:12921605
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13431402
    7WD40; WD40 repeat [structural motif]
  12. XM_006719494.3XP_006719557.1  kinesin-like protein KIF21A isoform X11

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13021612
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:12961609
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13471406
    7WD40; WD40 repeat [structural motif]
  13. XM_005269012.3XP_005269069.1  kinesin-like protein KIF21A isoform X10

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13031613
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:12971610
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13481407
    7WD40; WD40 repeat [structural motif]
  14. XM_005269011.3XP_005269068.1  kinesin-like protein KIF21A isoform X6

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13281638
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13221635
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13731432
    7WD40; WD40 repeat [structural motif]
  15. XM_005269008.3XP_005269065.1  kinesin-like protein KIF21A isoform X2

    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13411651
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13351648
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13861445
    7WD40; WD40 repeat [structural motif]
  16. XM_005269007.3XP_005269064.1  kinesin-like protein KIF21A isoform X1

    UniProtKB/Swiss-Prot
    Q7Z4S6
    Conserved Domains (7) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13461656
    WD40; WD40 repeat [General function prediction only]
    COG2882
    Location:668804
    FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
    cd00200
    Location:13401653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:8372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam02050
    Location:662799
    FliJ; Flagellar FliJ protein
    sd00039
    Location:13911450
    7WD40; WD40 repeat [structural motif]
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