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IL17RB interleukin 17 receptor B [ Homo sapiens (human) ]

Gene ID: 55540, updated on 1-Jun-2020

Summary

Official Symbol
IL17RBprovided by HGNC
Official Full Name
interleukin 17 receptor Bprovided by HGNC
Primary source
HGNC:HGNC:18015
See related
Ensembl:ENSG00000056736 MIM:605458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRL4; EVI27; IL17BR; IL17RH1
Summary
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues See more
Orthologs

Genomic context

See IL17RB in Genome Data Viewer
Location:
3p21.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (53846550..53867388)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53880577..53899827)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2578 Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene choline dehydrogenase Neighboring gene actin related protein 8 Neighboring gene selenoprotein K Neighboring gene uncharacterized LOC105377095

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-13 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-5 secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-17 receptor B
Names
IL-17 receptor B
IL-17 receptor homolog 1
IL-17B receptor
IL-17RB
IL-17Rh1
cytokine receptor CRL4
cytokine receptor-like 4
interleukin 17 receptor homolog 1
interleukin-17B receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018725.4NP_061195.2  interleukin-17 receptor B precursor

    See identical proteins and their annotated locations for NP_061195.2

    Status: REVIEWED

    Source sequence(s)
    BC000980, DA093617
    Consensus CDS
    CCDS2874.1
    UniProtKB/Swiss-Prot
    Q9NRM6
    Related
    ENSP00000288167.3, ENST00000288167.8
    Conserved Domains (3) summary
    pfam08357
    Location:332479
    SEFIR; SEFIR domain
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:176268
    IL17R_fnIII_D2; Interleukin 17 receptor D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    53846550..53867388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265310.5XP_005265367.1  interleukin-17 receptor B isoform X1

    Conserved Domains (3) summary
    pfam08357
    Location:361508
    SEFIR; SEFIR domain
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:176297
    IL17R_fnIII_D2; Interleukin 17 receptor D
  2. XM_011533941.3XP_011532243.1  interleukin-17 receptor B isoform X7

    Conserved Domains (2) summary
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:176297
    IL17R_fnIII_D2; Interleukin 17 receptor D
  3. XM_017006807.2XP_016862296.1  interleukin-17 receptor B isoform X9

    Related
    ENSP00000418638.1, ENST00000494338.1
  4. XM_005265311.5XP_005265368.1  interleukin-17 receptor B isoform X2

    Conserved Domains (3) summary
    pfam08357
    Location:345492
    SEFIR; SEFIR domain
    pfam16556
    Location:33169
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:161281
    IL17R_fnIII_D2; Interleukin 17 receptor D
  5. XM_005265312.5XP_005265369.1  interleukin-17 receptor B isoform X3

    Conserved Domains (3) summary
    pfam08357
    Location:316463
    SEFIR; SEFIR domain
    pfam16556
    Location:33169
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:161252
    IL17R_fnIII_D2; Interleukin 17 receptor D
  6. XM_024453634.1XP_024309402.1  interleukin-17 receptor B isoform X8

    Conserved Domains (1) summary
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
  7. XM_024453635.1XP_024309403.1  interleukin-17 receptor B isoform X10

    Conserved Domains (1) summary
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
  8. XM_024453636.1XP_024309404.1  interleukin-17 receptor B isoform X11

    Conserved Domains (1) summary
    pfam16556
    Location:33175
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
  9. XM_017006804.2XP_016862293.1  interleukin-17 receptor B isoform X4

    Conserved Domains (3) summary
    pfam08357
    Location:244391
    SEFIR; SEFIR domain
    pfam16556
    Location:158
    IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    pfam16578
    Location:59180
    IL17R_fnIII_D2; Interleukin 17 receptor D
  10. XM_017006806.2XP_016862295.1  interleukin-17 receptor B isoform X6

  11. XM_017006805.2XP_016862294.1  interleukin-17 receptor B isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172234.1: Suppressed sequence

    Description
    NM_172234.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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