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ELAC1 elaC ribonuclease Z 1 [ Homo sapiens (human) ]

Gene ID: 55520, updated on 13-Mar-2020

Summary

Official Symbol
ELAC1provided by HGNC
Official Full Name
elaC ribonuclease Z 1provided by HGNC
Primary source
HGNC:HGNC:14197
See related
Ensembl:ENSG00000141642 MIM:608079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D29
Expression
Ubiquitous expression in thyroid (RPKM 4.4), testis (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See ELAC1 in Genome Data Viewer
Location:
18q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (50968040..50988121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (48494387..48514491)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene maestro Neighboring gene ribosomal protein L17 pseudogene 46 Neighboring gene malic enzyme 2 Neighboring gene uncharacterized LOC107985152 Neighboring gene Sharpr-MPRA regulatory region 5267 Neighboring gene uncharacterized LOC105372117 Neighboring gene SMAD family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SMAD4

Homology

Clone Names

  • FLJ59261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
tRNA 3'-trailer cleavage, endonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc phosphodiesterase ELAC protein 1
Names
RNase Z 1
RNaseZ(S)
deleted in Ma29
elaC homolog 1
elaC homolog protein 1
ribonuclease Z 1
tRNA 3 endonuclease 1
tRNA 3' processing endoribonuclease
tRNA Z (short form)
tRNase Z 1
tRNase ZS
NP_061166.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018696.3NP_061166.1  zinc phosphodiesterase ELAC protein 1

    See identical proteins and their annotated locations for NP_061166.1

    Status: VALIDATED

    Source sequence(s)
    AC087687, AF308695, AI870985
    Consensus CDS
    CCDS11949.1
    UniProtKB/Swiss-Prot
    Q9H777
    Related
    ENSP00000269466.3, ENST00000269466.8
    Conserved Domains (2) summary
    COG1234
    Location:3360
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    TIGR02651
    Location:4359
    RNase_Z; ribonuclease Z

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    50968040..50988121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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