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SLC22A15 solute carrier family 22 member 15 [ Homo sapiens (human) ]

Gene ID: 55356, updated on 11-Jun-2021

Summary

Official Symbol
SLC22A15provided by HGNC
Official Full Name
solute carrier family 22 member 15provided by HGNC
Primary source
HGNC:HGNC:20301
See related
Ensembl:ENSG00000163393 MIM:608275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLIPT1; PRO34686
Summary
Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Expression
Broad expression in bone marrow (RPKM 6.8), skin (RPKM 3.1) and 19 other tissues See more
Orthologs
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Genomic context

See SLC22A15 in Genome Data Viewer
Location:
1p13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (115976513..116070054)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (116519134..116612675)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene uncharacterized LOC101928977 Neighboring gene long intergenic non-protein coding RNA 1649 Neighboring gene uncharacterized LOC105378918 Neighboring gene mab-21 like 3 Neighboring gene long intergenic non-protein coding RNA 1779

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • DKFZp761G0313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 15
Names
flipt 1
fly-like putative organic ion transporter 1
fly-like putative transporter 1
solute carrier family 22 (organic cation transporter), member 15
trans-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018420.3NP_060890.2  solute carrier family 22 member 15

    See identical proteins and their annotated locations for NP_060890.2

    Status: VALIDATED

    Source sequence(s)
    AL353933, AL357137, AL365318, BC026358, BC070033
    Consensus CDS
    CCDS44198.1
    UniProtKB/Swiss-Prot
    Q8IZD6
    Related
    ENSP00000358515.4, ENST00000369503.9
    Conserved Domains (2) summary
    cd06174
    Location:111469
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:111450
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    115976513..116070054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448238.1XP_024304006.1  solute carrier family 22 member 15 isoform X1

    Conserved Domains (1) summary
    cl26863
    Location:94394
    Sugar_tr; Sugar (and other) transporter
  2. XM_005271004.3XP_005271061.1  solute carrier family 22 member 15 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:111246
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_024448239.1XP_024304007.1  solute carrier family 22 member 15 isoform X2

    Conserved Domains (1) summary
    cl26863
    Location:94394
    Sugar_tr; Sugar (and other) transporter

RNA

  1. XR_002957029.1 RNA Sequence

  2. XR_002957027.1 RNA Sequence

  3. XR_002957031.1 RNA Sequence

  4. XR_002957032.1 RNA Sequence

  5. XR_002957030.1 RNA Sequence

  6. XR_002957033.1 RNA Sequence

  7. XR_002957034.1 RNA Sequence

  8. XR_002957035.1 RNA Sequence

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