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SLC22A15 solute carrier family 22 member 15 [ Homo sapiens (human) ]

Gene ID: 55356, updated on 22-Sep-2022

Summary

Official Symbol
SLC22A15provided by HGNC
Official Full Name
solute carrier family 22 member 15provided by HGNC
Primary source
HGNC:HGNC:20301
See related
Ensembl:ENSG00000163393 MIM:608275; AllianceGenome:HGNC:20301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLIPT1; PRO34686
Summary
Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Expression
Broad expression in bone marrow (RPKM 6.8), skin (RPKM 3.1) and 19 other tissues See more
Orthologs
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Genomic context

See SLC22A15 in Genome Data Viewer
Location:
1p13.1
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (115976513..116070054)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (115984504..116078027)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (116519134..116612675)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A-like Neighboring gene uncharacterized LOC101928977 Neighboring gene long intergenic non-protein coding RNA 1649 Neighboring gene uncharacterized LOC105378918 Neighboring gene mab-21 like 3 Neighboring gene Sharpr-MPRA regulatory region 11424

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761G0313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 15
Names
flipt 1
fly-like putative organic ion transporter 1
fly-like putative transporter 1
solute carrier family 22 (organic cation transporter), member 15
trans-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018420.3NP_060890.2  solute carrier family 22 member 15

    See identical proteins and their annotated locations for NP_060890.2

    Status: VALIDATED

    Source sequence(s)
    AL353933, AL357137, AL365318, BC026358, BC070033
    Consensus CDS
    CCDS44198.1
    UniProtKB/Swiss-Prot
    Q8IZD6, Q9NSH5
    Related
    ENSP00000358515.4, ENST00000369503.9
    Conserved Domains (1) summary
    cd17377
    Location:71469
    MFS_SLC22A15; Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    115976513..116070054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424416.1XP_047280372.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0
  2. XM_047424412.1XP_047280368.1  solute carrier family 22 member 15 isoform X3

  3. XM_047424411.1XP_047280367.1  solute carrier family 22 member 15 isoform X2

  4. XM_047424415.1XP_047280371.1  solute carrier family 22 member 15 isoform X7

  5. XM_047424414.1XP_047280370.1  solute carrier family 22 member 15 isoform X5

  6. XM_024448239.2XP_024304007.1  solute carrier family 22 member 15 isoform X8

    Conserved Domains (1) summary
    cl26863
    Location:94394
    Sugar_tr; Sugar (and other) transporter
  7. XM_024448238.2XP_024304006.1  solute carrier family 22 member 15 isoform X6

    Conserved Domains (1) summary
    cl26863
    Location:94394
    Sugar_tr; Sugar (and other) transporter
  8. XM_005271004.4XP_005271061.1  solute carrier family 22 member 15 isoform X10

    Conserved Domains (1) summary
    cd06174
    Location:111246
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  9. XM_047424419.1XP_047280375.1  solute carrier family 22 member 15 isoform X12

  10. XM_047424420.1XP_047280376.1  solute carrier family 22 member 15 isoform X13

  11. XM_047424422.1XP_047280378.1  solute carrier family 22 member 15 isoform X15

    Related
    ENSP00000358514.1, ENST00000369502.1
  12. XM_047424417.1XP_047280373.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0
  13. XM_047424413.1XP_047280369.1  solute carrier family 22 member 15 isoform X4

  14. XM_047424410.1XP_047280366.1  solute carrier family 22 member 15 isoform X1

  15. XM_047424418.1XP_047280374.1  solute carrier family 22 member 15 isoform X11

  16. XM_047424421.1XP_047280377.1  solute carrier family 22 member 15 isoform X14

RNA

  1. XR_002957027.2 RNA Sequence

  2. XR_002957032.2 RNA Sequence

  3. XR_007061934.1 RNA Sequence

  4. XR_007061933.1 RNA Sequence

  5. XR_007061932.1 RNA Sequence

  6. XR_007061935.1 RNA Sequence

  7. XR_007061937.1 RNA Sequence

  8. XR_007061936.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    115984504..116078027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)