Format

Send to:

Choose Destination

AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 55326, updated on 4-Oct-2020

Summary

Official Symbol
AGPAT5provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:20886
See related
Ensembl:ENSG00000155189 MIM:614796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAATE; 1AGPAT5
Summary
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Expression
Broad expression in testis (RPKM 16.0), brain (RPKM 13.8) and 23 other tissues See more
Orthologs

Genomic context

See AGPAT5 in Genome Data Viewer
Location:
8p23.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (6708587..6761503)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6565878..6619024)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microcephalin 1 Neighboring gene angiopoietin 2 Neighboring gene MCPH1 antisense RNA 1 Neighboring gene microRNA 8055 Neighboring gene protein tyrosine phosphatase non-receptor type 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 12268 Neighboring gene microRNA 4659a Neighboring gene microRNA 4659b Neighboring gene uncharacterized LOC107986909 Neighboring gene XK related 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
Names
1-AGP acyltransferase 5
1-AGPAT 5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
lysophosphatidic acid acyltransferase epsilon
testicular tissue protein Li 144
NP_060831.2
XP_011533053.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018361.5NP_060831.2  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

    See identical proteins and their annotated locations for NP_060831.2

    Status: REVIEWED

    Source sequence(s)
    AF287957
    Consensus CDS
    CCDS34796.1
    UniProtKB/Swiss-Prot
    Q9NUQ2
    UniProtKB/TrEMBL
    A0A024R640
    Related
    ENSP00000285518.6, ENST00000285518.11
    Conserved Domains (3) summary
    cd07990
    Location:63263
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    COG0204
    Location:34281
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam16076
    Location:258318
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    6708587..6761503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534751.2XP_011533053.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    Conserved Domains (1) summary
    cd07990
    Location:63166
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    103912..156773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center