Format

Send to:

Choose Destination

LARP6 La ribonucleoprotein 6, translational regulator [ Homo sapiens (human) ]

Gene ID: 55323, updated on 24-Nov-2020

Summary

Official Symbol
LARP6provided by HGNC
Official Full Name
La ribonucleoprotein 6, translational regulatorprovided by HGNC
Primary source
HGNC:HGNC:24012
See related
Ensembl:ENSG00000166173 MIM:611300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACHN
Expression
Broad expression in brain (RPKM 22.8), thyroid (RPKM 15.1) and 17 other tissues See more
Orthologs

Genomic context

See LARP6 in Genome Data Viewer
Location:
15q23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (70829130..70854157, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (71123889..71146498, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats Neighboring gene ribosomal protein L29 pseudogene 30 Neighboring gene leucine rich repeat containing 49 Neighboring gene keratin 8 pseudogene 9 Neighboring gene THAP domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA stem-loop binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA stem-loop binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
polysome IDA
Inferred from Direct Assay
more info
PubMed 
polysome IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
la-related protein 6
Names
La ribonucleoprotein domain family member 6
acheron
death-associated LA motif protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286679.2NP_001273608.1  la-related protein 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC009269, AC090868, AI376944, AL833876, DA715263
    UniProtKB/Swiss-Prot
    Q9BRS8
    Conserved Domains (2) summary
    cd12289
    Location:1108
    RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins
    pfam12901
    Location:284298
    SUZ-C; SUZ-C motif
  2. NM_018357.4NP_060827.2  la-related protein 6 isoform 1

    See identical proteins and their annotated locations for NP_060827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009269, AI376944, AL833876, DN992782
    Consensus CDS
    CCDS32281.1
    UniProtKB/Swiss-Prot
    Q9BRS8
    Related
    ENSP00000299213.7, ENST00000299213.10
    Conserved Domains (2) summary
    cd08033
    Location:93169
    LARP_6; La RNA-binding domain of La-related protein 6
    cd12289
    Location:184292
    RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins
  3. NM_197958.3NP_932062.1  la-related protein 6 isoform 2

    See identical proteins and their annotated locations for NP_932062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC039153, DN992782
    Consensus CDS
    CCDS10236.1
    UniProtKB/Swiss-Prot
    Q9BRS8
    Related
    ENSP00000343869.3, ENST00000344870.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    70829130..70854157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center