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AVPR1B arginine vasopressin receptor 1B [ Homo sapiens (human) ]

Gene ID: 553, updated on 19-Jun-2022

Summary

Official Symbol
AVPR1Bprovided by HGNC
Official Full Name
arginine vasopressin receptor 1Bprovided by HGNC
Primary source
HGNC:HGNC:896
See related
Ensembl:ENSG00000198049 MIM:600264; AllianceGenome:HGNC:896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V1bR; VPR3; AVPR3
Summary
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See AVPR1B in Genome Data Viewer
Location:
1q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206106936..206117388, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205370978..205381434, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206223943..206234395)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372857 Neighboring gene regulator of hemoglobinization and erythroid cell expansion Neighboring gene Sharpr-MPRA regulatory region 5780 Neighboring gene small nucleolar RNA SNORD60 Neighboring gene uncharacterized LOC124904492 Neighboring gene Sharpr-MPRA regulatory region 13667 Neighboring gene uncharacterized LOC105372869

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C binding TAS
Traceable Author Statement
more info
PubMed 
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vasopressin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hyperosmotic salinity response IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular pH reduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vasopressin V1b receptor
Names
AVPR V1b
AVPR V3
V1B receptor
antidiuretic hormone receptor 1B
arginine vasopressin receptor 3
pituitary vasopressin receptor 3
vasopressin V3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000707.5NP_000698.1  vasopressin V1b receptor

    See identical proteins and their annotated locations for NP_000698.1

    Status: REVIEWED

    Source sequence(s)
    AC244035, D31833
    Consensus CDS
    CCDS73015.1
    UniProtKB/Swiss-Prot
    P47901
    Related
    ENSP00000356094.4, ENST00000367126.5
    Conserved Domains (3) summary
    pfam00001
    Location:51338
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam08983
    Location:362412
    DUF1856; Domain of unknown function (DUF1856)
    cl21561
    Location:52222
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206106936..206117388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205370978..205381434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)