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BRF2 BRF2 RNA polymerase III transcription initiation factor subunit [ Homo sapiens (human) ]

Gene ID: 55290, updated on 23-Nov-2021

Summary

Official Symbol
BRF2provided by HGNC
Official Full Name
BRF2 RNA polymerase III transcription initiation factor subunitprovided by HGNC
Primary source
HGNC:HGNC:17298
See related
Ensembl:ENSG00000104221 MIM:607013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRFU; TFIIIB50
Summary
This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues See more
Orthologs
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Genomic context

See BRF2 in Genome Data Viewer
Location:
8p11.23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37843268..37849861, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37700786..37707379, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379381 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer hs1665 Neighboring gene RAB11 family interacting protein 1 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIIIB complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor IIIB 50 kDa subunit
Names
B-related factor 2
BRF-2
BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
RNA polymerase III transcription initiation factor BRFU
hBRFU
hTFIIIB50
transcription factor IIB- related factor, TFIIIB50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046965.1 RefSeqGene

    Range
    5053..11646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018310.4NP_060780.2  transcription factor IIIB 50 kDa subunit

    See identical proteins and their annotated locations for NP_060780.2

    Status: REVIEWED

    Source sequence(s)
    AA496239, AC138356, AF206673, AK001914
    Consensus CDS
    CCDS6098.1
    UniProtKB/Swiss-Prot
    Q9HAW0
    Related
    ENSP00000220659.6, ENST00000220659.11
    Conserved Domains (1) summary
    COG1405
    Location:5233
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    37843268..37849861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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