Format

Send to:

Choose Destination

TYW1 tRNA-yW synthesizing protein 1 homolog [ Homo sapiens (human) ]

Gene ID: 55253, updated on 8-Nov-2020

Summary

Official Symbol
TYW1provided by HGNC
Official Full Name
tRNA-yW synthesizing protein 1 homologprovided by HGNC
Primary source
HGNC:HGNC:25598
See related
Ensembl:ENSG00000198874 MIM:611243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TYW1A; RSAFD1; YPL207W
Summary
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in thyroid (RPKM 5.7), ovary (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See TYW1 in Genome Data Viewer
Location:
7q11.21
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (66996830..67239515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (66461792..66704507)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 43, pseudogene Neighboring gene SBDS ribosome maturation factor Neighboring gene microRNA 4650-1 Neighboring gene speedy/RINGO cell cycle regulator family member E21 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 4 Neighboring gene stromal antigen 3-like 4 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10900, MGC23001, MGC60291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
FMN binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tRNA-4-demethylwyosine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1
Names
radical S-adenosyl methionine and flavodoxin domain-containing protein 1
radical S-adenosyl methionine and flavodoxin domains 1
tRNA wybutosine-synthesizing protein 1 homolog
tRNA-yW synthesizing protein 1 homolog A
NP_060734.2
XP_011514674.1
XP_016867881.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033069.1 RefSeqGene

    Range
    5029..247710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018264.4NP_060734.2  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

    See identical proteins and their annotated locations for NP_060734.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC006480, AC073089, AC079920
    Consensus CDS
    CCDS5538.1
    UniProtKB/Swiss-Prot
    Q9NV66
    Related
    ENSP00000352645.5, ENST00000359626.10
    Conserved Domains (2) summary
    PRK13762
    Location:351656
    PRK13762; 4-demethylwyosine synthase TYW1
    pfam00258
    Location:81232
    Flavodoxin_1

RNA

  1. NR_134540.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC015591, BC051888, BM678114, HY014014
    Related
    ENST00000361660.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    66996830..67239515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012392.2XP_016867881.1  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform X2

    Conserved Domains (2) summary
    PRK13762
    Location:368562
    PRK13762; 4-demethylwyosine synthase TYW1
    pfam00258
    Location:81232
    Flavodoxin_1
  2. XM_011516372.3XP_011514674.1  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform X1

    Conserved Domains (2) summary
    PRK13762
    Location:351664
    PRK13762; 4-demethylwyosine synthase TYW1
    pfam00258
    Location:81232
    Flavodoxin_1

RNA

  1. XR_001744831.2 RNA Sequence

  2. XR_001744833.2 RNA Sequence

  3. XR_001744832.2 RNA Sequence

  4. XR_001744834.2 RNA Sequence

  5. XR_002956462.1 RNA Sequence

Support Center