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CCDC25 coiled-coil domain containing 25 [ Homo sapiens (human) ]

Gene ID: 55246, updated on 2-Nov-2024

Summary

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Official Symbol
CCDC25provided by HGNC
Official Full Name
coiled-coil domain containing 25provided by HGNC
Primary source
HGNC:HGNC:25591
See related
Ensembl:ENSG00000147419 MIM:619100; AllianceGenome:HGNC:25591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum (RPKM 17.8), small intestine (RPKM 15.9) and 25 other tissues See more
Orthologs
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Genomic context

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See CCDC25 in Genome Data Viewer
Location:
8p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27733316..27772640, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28010681..28050010, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27590833..27630157, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A member 3 Neighboring gene uncharacterized LOC124901921 Neighboring gene uncharacterized LOC124901920 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27560651-27560796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27562294-27562794 Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27587170-27587710 Neighboring gene uncharacterized LOC107986934 Neighboring gene uncharacterized LOC124902093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19051 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene PDZ binding kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome. Phimphila A, et al. In Vivo, 2024 Mar-Apr. PMID 38418150, Free PMC Article
  2. Coiled-coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK-NF-κB signaling pathway. Qian Z, et al. FASEB J, 2024 Jan 31. PMID 38236371
  3. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation. Tang Q, et al. Sci Rep, 2022 Oct 17. PMID 36253427, Free PMC Article
  4. High expression of CCDC25 in cholangiocarcinoma tissue samples. Proungvitaya S, et al. Oncol Lett, 2017 Aug. PMID 28789463, Free PMC Article
  5. Role of CD61(+) low-density neutrophils in promoting hepatocellular carcinoma metastasis through CCDC25 upregulation. Guan X, et al. Int Immunopharmacol, 2024 Jun 15. PMID 38761780

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of CD61[+] low-density neutrophils in promoting hepatocellular carcinoma metastasis through CCDC25 upregulation.
    Title: Role of CD61(+) low-density neutrophils in promoting hepatocellular carcinoma metastasis through CCDC25 upregulation.
  2. Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome.
    Title: Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome.
  3. Coiled-coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK-NF-kappaB signaling pathway.
    Title: Coiled-coil domain containing 25 (CCDC25) regulates cell proliferation, migration, and invasion in clear cell renal cell carcinoma by targeting the ILK-NF-κB signaling pathway.
  4. Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
    Title: Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
  5. CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road.
    Title: CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road.
  6. Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
    Title: Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis.
  7. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
    Title: DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304529.2 → NP_001291458.1  coiled-coil domain-containing protein 25 isoform 2

    See identical proteins and their annotated locations for NP_001291458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region which results in a frame shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AC104997, BC065295, BU602778
    Consensus CDS
    CCDS78324.1
    UniProtKB/TrEMBL
    G3V121
    Related
    ENSP00000429861.1, ENST00000524084.5
    Conserved Domains (1) summary
    pfam05670
    Location:12 → 82
    DUF814; Domain of unknown function (DUF814)

  2. NM_001304530.2 → NP_001291459.1  coiled-coil domain-containing protein 25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. These difference result in the uses a downstream start codon and frameshift in the 3' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AC104997, BC065295, BG718771
    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    pfam05670
    Location:1 → 32
    DUF814; Domain of unknown function (DUF814)

  3. NM_001304532.2 → NP_001291461.1  coiled-coil domain-containing protein 25 isoform 4

    See identical proteins and their annotated locations for NP_001291461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AK001715, BC065295
    Consensus CDS
    CCDS78323.1
    UniProtKB/Swiss-Prot
    Q86WR0
    Related
    ENSP00000428000.1, ENST00000522915.5
    Conserved Domains (1) summary
    cl05307
    Location:1 → 44
    DUF814; Domain of unknown function (DUF814)

  4. NM_018246.3 → NP_060716.2  coiled-coil domain-containing protein 25 isoform 1

    See identical proteins and their annotated locations for NP_060716.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC013643, BC065295, DA218015
    Consensus CDS
    CCDS6062.2
    UniProtKB/Swiss-Prot
    Q0P663, Q86WR0, Q96SI2, Q9NV98
    UniProtKB/TrEMBL
    Q7Z5U5
    Related
    ENSP00000348933.4, ENST00000356537.9
    Conserved Domains (1) summary
    pfam05670
    Location:1 → 112
    DUF814; Domain of unknown function (DUF814)

RNA

  1. NR_130761.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013643, AC104997, AK316015, BC065295

  2. NR_130762.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013643, AK001715, BC065295, BC110391
    Related
    ENST00000520486.5

  3. NR_156432.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC013643, BC065295, DC307301

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27733316..27772640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544571.3 → XP_011542873.1  coiled-coil domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011542873.1

    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    cl05307
    Location:1 → 44
    DUF814; Domain of unknown function (DUF814)

  2. XM_011544570.3 → XP_011542872.1  coiled-coil domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011542872.1

    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    cl05307
    Location:1 → 44
    DUF814; Domain of unknown function (DUF814)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    28010681..28050010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360767.1 → XP_054216742.1  coiled-coil domain-containing protein 25 isoform X1

  2. XM_054360766.1 → XP_054216741.1  coiled-coil domain-containing protein 25 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WR0.2 GenPept UniProtKB/Swiss-Prot:Q86WR0

Gene LinkOut

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