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CCDC25 coiled-coil domain containing 25 [ Homo sapiens (human) ]

Gene ID: 55246, updated on 7-Jun-2020

Summary

Official Symbol
CCDC25provided by HGNC
Official Full Name
coiled-coil domain containing 25provided by HGNC
Primary source
HGNC:HGNC:25591
See related
Ensembl:ENSG00000147419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in duodenum (RPKM 17.8), small intestine (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See CCDC25 in Genome Data Viewer
Location:
8p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27733316..27772640, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27590833..27630170, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A member 3 Neighboring gene RNA, U6 small nuclear 1086, pseudogene Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene uncharacterized LOC107986934 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene PDZ binding kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304529.2NP_001291458.1  coiled-coil domain-containing protein 25 isoform 2

    See identical proteins and their annotated locations for NP_001291458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region which results in a frame shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AC104997, BC065295, BU602778
    Consensus CDS
    CCDS78324.1
    UniProtKB/Swiss-Prot
    Q86WR0
    UniProtKB/TrEMBL
    G3V121
    Related
    ENSP00000429861.1, ENST00000524084.5
    Conserved Domains (1) summary
    pfam05670
    Location:1282
    DUF814; Domain of unknown function (DUF814)
  2. NM_001304530.2NP_001291459.1  coiled-coil domain-containing protein 25 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. These difference result in the uses a downstream start codon and frameshift in the 3' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AC104997, BC065295, BG718771
    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    pfam05670
    Location:132
    DUF814; Domain of unknown function (DUF814)
  3. NM_001304532.2NP_001291461.1  coiled-coil domain-containing protein 25 isoform 4

    See identical proteins and their annotated locations for NP_001291461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC013643, AK001715, BC065295
    Consensus CDS
    CCDS78323.1
    UniProtKB/Swiss-Prot
    Q86WR0
    Related
    ENSP00000428000.1, ENST00000522915.5
    Conserved Domains (1) summary
    pfam05670
    Location:132
    DUF814; Domain of unknown function (DUF814)
  4. NM_018246.3NP_060716.2  coiled-coil domain-containing protein 25 isoform 1

    See identical proteins and their annotated locations for NP_060716.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC013643, BC065295, DA218015
    Consensus CDS
    CCDS6062.2
    UniProtKB/Swiss-Prot
    Q86WR0
    Related
    ENSP00000348933.4, ENST00000356537.9
    Conserved Domains (1) summary
    pfam05670
    Location:4100
    DUF814; Domain of unknown function (DUF814)

RNA

  1. NR_130761.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013643, AC104997, AK316015, BC065295
  2. NR_130762.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013643, AK001715, BC065295, BC110391
    Related
    ENST00000520486.5
  3. NR_156432.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC013643, BC065295, DC307301

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    27733316..27772640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544570.2XP_011542872.1  coiled-coil domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011542872.1

    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    pfam05670
    Location:132
    DUF814; Domain of unknown function (DUF814)
  2. XM_011544571.2XP_011542873.1  coiled-coil domain-containing protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011542873.1

    UniProtKB/Swiss-Prot
    Q86WR0
    Conserved Domains (1) summary
    pfam05670
    Location:132
    DUF814; Domain of unknown function (DUF814)
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