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STEAP3 STEAP3 metalloreductase [ Homo sapiens (human) ]

Gene ID: 55240, updated on 8-Jul-2021

Summary

Official Symbol
STEAP3provided by HGNC
Official Full Name
STEAP3 metalloreductaseprovided by HGNC
Primary source
HGNC:HGNC:24592
See related
Ensembl:ENSG00000115107 MIM:609671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STMP3; TSAP6; pHyde; AHMIO2; dudlin-2; dudulin-2
Summary
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in liver (RPKM 27.2), duodenum (RPKM 11.9) and 23 other tissues See more
Orthologs
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Genomic context

See STEAP3 in Genome Data Viewer
Location:
2q14.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (119222476..119265652)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119981410..120023228)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985941 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene STEAP3 antisense RNA 1 Neighboring gene uncharacterized LOC105373581 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene transmembrane protein 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
GeneReviews: Not available
Hypochromic microcytic anemia with iron overload 2
MedGen: C3808920 OMIM: 615234 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transferrin transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
metalloreductase STEAP3
Names
STEAP family member 3, metalloreductase
six-transmembrane epithelial antigen of prostate 3
tumor suppressor pHyde
tumor suppressor-activated pathway protein 6
NP_001008410.1
NP_060704.2
NP_619543.2
NP_878919.2
XP_006712677.1
XP_006712678.1
XP_011509705.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042823.1 RefSeqGene

    Range
    5027..46845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008410.2NP_001008410.1  metalloreductase STEAP3 isoform b

    See identical proteins and their annotated locations for NP_001008410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC016736, AY214461, BM146930
    Consensus CDS
    CCDS2125.1
    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    A0A024RAD7
    Related
    ENSP00000376819.2, ENST00000393107.2
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  2. NM_018234.3NP_060704.2  metalloreductase STEAP3 isoform b

    See identical proteins and their annotated locations for NP_060704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' region, and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC016736, AY214461
    Consensus CDS
    CCDS2125.1
    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    A0A024RAD7
    Related
    ENSP00000376818.2, ENST00000393106.6
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  3. NM_138637.3NP_619543.2  metalloreductase STEAP3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. It initiates translation at a downstream start codon, and contains a frameshift in the 3' coding region. The resulting isoform (c) is shorter at the N-terminus and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC016736, AF262322, AF423424, AL833624
    Consensus CDS
    CCDS82504.1
    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    B8ZZX6
    Related
    ENSP00000386510.1, ENST00000409811.5
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262394
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  4. NM_182915.3NP_878919.2  metalloreductase STEAP3 isoform a

    See identical proteins and their annotated locations for NP_878919.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC016736, AL833624, BX538047
    Consensus CDS
    CCDS42738.1
    UniProtKB/Swiss-Prot
    Q658P3
    Related
    ENSP00000376822.2, ENST00000393110.7
    Conserved Domains (3) summary
    COG2085
    Location:39219
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:272415
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:42127
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    119222476..119265652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712614.3XP_006712677.1  metalloreductase STEAP3 isoform X1

    See identical proteins and their annotated locations for XP_006712677.1

    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    A0A024RAD7
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  2. XM_011511403.1XP_011509705.1  metalloreductase STEAP3 isoform X1

    See identical proteins and their annotated locations for XP_011509705.1

    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    A0A024RAD7
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
  3. XM_006712615.1XP_006712678.1  metalloreductase STEAP3 isoform X1

    See identical proteins and their annotated locations for XP_006712678.1

    UniProtKB/Swiss-Prot
    Q658P3
    UniProtKB/TrEMBL
    A0A024RAD7
    Conserved Domains (3) summary
    COG2085
    Location:29209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:32117
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
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