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CENPQ centromere protein Q [ Homo sapiens (human) ]

Gene ID: 55166, updated on 27-Nov-2024

Summary

Official Symbol
CENPQprovided by HGNC
Official Full Name
centromere protein Qprovided by HGNC
Primary source
HGNC:HGNC:21347
See related
Ensembl:ENSG00000031691 MIM:611506; AllianceGenome:HGNC:21347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-Q; C6orf139
Summary
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See CENPQ in Genome Data Viewer
Location:
6p12.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49463370..49493107)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49305401..49335269)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49431083..49460820)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49354927-49355469 Neighboring gene methylmalonyl-CoA mutase Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:49430149-49431049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:49431050-49431949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49450846-49451350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49451351-49451854 Neighboring gene glycine-N-acyltransferase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:49519182-49519701 Neighboring gene chromosome 6 open reading frame 141

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10545

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of inner kinetochore IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018132.4NP_060602.2  centromere protein Q

    See identical proteins and their annotated locations for NP_060602.2

    Status: VALIDATED

    Source sequence(s)
    AL590244, AL590668
    Consensus CDS
    CCDS4925.1
    UniProtKB/Swiss-Prot
    A8KAF1, Q6IN61, Q7L2Z9, Q9NVS5
    Related
    ENSP00000337289.2, ENST00000335783.4
    Conserved Domains (1) summary
    pfam13094
    Location:116266
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    49463370..49493107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249205.2XP_005249262.1  centromere protein Q isoform X1

    See identical proteins and their annotated locations for XP_005249262.1

    UniProtKB/Swiss-Prot
    A8KAF1, Q6IN61, Q7L2Z9, Q9NVS5
    Conserved Domains (1) summary
    pfam13094
    Location:116266
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    49305401..49335269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355772.1XP_054211747.1  centromere protein Q isoform X1