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CENPQ centromere protein Q [ Homo sapiens (human) ]

Gene ID: 55166, updated on 18-Aug-2020

Summary

Official Symbol
CENPQprovided by HGNC
Official Full Name
centromere protein Qprovided by HGNC
Primary source
HGNC:HGNC:21347
See related
Ensembl:ENSG00000031691 MIM:611506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-Q; C6orf139
Summary
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See CENPQ in Genome Data Viewer
Location:
6p12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (49463327..49493107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49431054..49460820)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 42 Neighboring gene methylmalonyl-CoA mutase Neighboring gene glycine-N-acyltransferase like 3 Neighboring gene chromosome 6 open reading frame 141

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10545

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018132.4NP_060602.2  centromere protein Q

    See identical proteins and their annotated locations for NP_060602.2

    Status: VALIDATED

    Source sequence(s)
    AL590244, AL590668
    Consensus CDS
    CCDS4925.1
    UniProtKB/Swiss-Prot
    Q7L2Z9
    Related
    ENSP00000337289.2, ENST00000335783.4
    Conserved Domains (1) summary
    pfam13094
    Location:116266
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    49463327..49493107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514723.2XP_011513025.2  centromere protein Q isoform X1

  2. XM_005249205.1XP_005249262.1  centromere protein Q isoform X2

    See identical proteins and their annotated locations for XP_005249262.1

    UniProtKB/Swiss-Prot
    Q7L2Z9
    Conserved Domains (1) summary
    pfam13094
    Location:116266
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
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