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MSTO1 misato mitochondrial distribution and morphology regulator 1 [ Homo sapiens (human) ]

Gene ID: 55154, updated on 1-Aug-2020

Summary

Official Symbol
MSTO1provided by HGNC
Official Full Name
misato mitochondrial distribution and morphology regulator 1provided by HGNC
Primary source
HGNC:HGNC:29678
See related
Ensembl:ENSG00000125459 MIM:617619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; MMYAT; LST005
Expression
Ubiquitous expression in testis (RPKM 18.6), fat (RPKM 12.3) and 25 other tissues See more
Orthologs

Genomic context

See MSTO1 in Genome Data Viewer
Location:
1q22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155610170..155614967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155579961..155584758)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene claudin 6 pseudogene Neighboring gene death associated protein 3 pseudogene 1 Neighboring gene uncharacterized LOC105371452 Neighboring gene gon-4 like pseudogene Neighboring gene gon-4 like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
MedGen: C4540096 OMIM: 617675 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10504, DKFZp686B1757, DKFZp686I01261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein misato homolog 1
Names
misato 1, mitochondrial distribution and morphology regulator
misato homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256532.1NP_001243461.1  protein misato homolog 1 isoform b

    See identical proteins and their annotated locations for NP_001243461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AF272833, AK222863, BC002535, DA807092
    UniProtKB/Swiss-Prot
    Q9BUK6
    Conserved Domains (1) summary
    cd06060
    Location:6562
    misato; Misato segment II tubulin-like domain
  2. NM_001256533.1NP_001243462.1  protein misato homolog 1 isoform c

    See identical proteins and their annotated locations for NP_001243462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AF272833, BC002535, CR749791, DA807092
    UniProtKB/Swiss-Prot
    Q9BUK6
    Conserved Domains (1) summary
    cd06060
    Location:6551
    misato; Misato segment II tubulin-like domain
  3. NM_001350772.1NP_001337701.1  protein misato homolog 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF272833, BC002535, CR749791, DA807092
    Related
    ENSP00000357325.4, ENST00000368341.8
    Conserved Domains (1) summary
    cd06060
    Location:6552
    misato; Misato segment II tubulin-like domain
  4. NM_001350773.1NP_001337702.1  protein misato homolog 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  5. NM_001350774.1NP_001337703.1  protein misato homolog 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA807092
    Related
    ENSP00000498188.1, ENST00000649846.1
    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  6. NM_001350775.1NP_001337704.1  protein misato homolog 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BX421996, DA807092, H12094
    Conserved Domains (1) summary
    cd06060
    Location:6511
    misato; Misato segment II tubulin-like domain
  7. NM_001350776.1NP_001337705.1  protein misato homolog 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BF027217, DA070565, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:88508
    misato; Misato segment II tubulin-like domain
  8. NM_001350777.1NP_001337706.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  9. NM_001350778.1NP_001337707.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA272145, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  10. NM_001350779.1NP_001337708.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA379275, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  11. NM_001350780.1NP_001337709.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  12. NM_001350781.1NP_001337710.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, AY334564, BC002535, DA070565, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  13. NM_001350782.1NP_001337711.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  14. NM_001350783.1NP_001337712.1  protein misato homolog 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:1384
    misato; Misato segment II tubulin-like domain
  15. NM_001350784.1NP_001337713.1  protein misato homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA379275, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain
  16. NM_001350785.1NP_001337714.1  protein misato homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, AY334564, BC002535, DA272145, DA379275, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain
  17. NM_001350786.1NP_001337715.1  protein misato homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA070565, DA272145, DA807092
    Conserved Domains (1) summary
    cl10017
    Location:1250
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  18. NM_001350787.1NP_001337716.1  protein misato homolog 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, CR749791, DA379275, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:7371
    misato; Misato segment II tubulin-like domain
  19. NM_001350788.1NP_001337717.1  protein misato homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
    Conserved Domains (1) summary
    cd06060
    Location:1333
    misato; Misato segment II tubulin-like domain
  20. NM_001350789.1NP_001337718.1  protein misato homolog 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
    Conserved Domains (1) summary
    cl10017
    Location:7330
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  21. NM_018116.4NP_060586.2  protein misato homolog 1 isoform a

    See identical proteins and their annotated locations for NP_060586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF272833, AK001366, AK222863, BX537684
    Consensus CDS
    CCDS1114.1
    UniProtKB/Swiss-Prot
    Q9BUK6
    Related
    ENSP00000245564.2, ENST00000245564.7
    Conserved Domains (1) summary
    cd06060
    Location:6563
    misato; Misato segment II tubulin-like domain

RNA

  1. NR_046292.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, AK297140, AK309573, AL353807, BC002535, DA807092
  2. NR_046293.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, AK309573, BC002535, DA807092
  3. NR_046294.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK056128, DA807092
    Related
    ENST00000494995.5
  4. NR_046295.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, BC002535, BX537684, DA807092
    Related
    ENST00000490743.5
  5. NR_146907.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA807092
  6. NR_146908.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BX421996, DA807092

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155610170..155614967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448046.1XP_024303814.1  protein misato homolog 1 isoform X11

    Conserved Domains (1) summary
    cl10017
    Location:11251
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  2. XM_024448048.1XP_024303816.1  protein misato homolog 1 isoform X13

    Conserved Domains (1) summary
    cl10017
    Location:11335
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  3. XM_024448044.1XP_024303812.1  protein misato homolog 1 isoform X10

    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain
  4. XM_011509703.2XP_011508005.1  protein misato homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011508005.1

    Conserved Domains (1) summary
    cd06060
    Location:88508
    misato; Misato segment II tubulin-like domain
  5. XM_017001605.2XP_016857094.1  protein misato homolog 1 isoform X7

    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  6. XM_011509707.2XP_011508009.1  protein misato homolog 1 isoform X8

    See identical proteins and their annotated locations for XP_011508009.1

    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  7. XM_011509704.2XP_011508006.1  protein misato homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011508006.1

    Conserved Domains (1) summary
    cd06060
    Location:88508
    misato; Misato segment II tubulin-like domain
  8. XM_017001606.2XP_016857095.1  protein misato homolog 1 isoform X8

    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  9. XM_011509708.2XP_011508010.1  protein misato homolog 1 isoform X9

    See identical proteins and their annotated locations for XP_011508010.1

    UniProtKB/Swiss-Prot
    Q9BUK6
    Related
    ENST00000483734.5
    Conserved Domains (1) summary
    cd06060
    Location:1384
    misato; Misato segment II tubulin-like domain
  10. XM_024448042.1XP_024303810.1  protein misato homolog 1 isoform X8

    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  11. XM_011509695.2XP_011507997.1  protein misato homolog 1 isoform X1

    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  12. XM_011509700.2XP_011508002.1  protein misato homolog 1 isoform X2

    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  13. XM_011509701.2XP_011508003.1  protein misato homolog 1 isoform X3

    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  14. XM_011509702.2XP_011508004.1  protein misato homolog 1 isoform X4

    Conserved Domains (1) summary
    cd06060
    Location:6512
    misato; Misato segment II tubulin-like domain
  15. XM_011509709.3XP_011508011.1  protein misato homolog 1 isoform X12

    Conserved Domains (1) summary
    cd06060
    Location:6366
    misato; Misato segment II tubulin-like domain
  16. XM_011509705.1XP_011508007.1  protein misato homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011508007.1

    Conserved Domains (1) summary
    cd06060
    Location:88508
    misato; Misato segment II tubulin-like domain
  17. XM_024448039.1XP_024303807.1  protein misato homolog 1 isoform X6

    Conserved Domains (1) summary
    cd06060
    Location:1494
    misato; Misato segment II tubulin-like domain
  18. XM_024448043.1XP_024303811.1  protein misato homolog 1 isoform X10

    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain

RNA

  1. XR_002956984.1 RNA Sequence

  2. XR_001737275.2 RNA Sequence

  3. XR_001737273.2 RNA Sequence

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