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SDAD1 SDA1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55153, updated on 5-Jul-2020

Summary

Official Symbol
SDAD1provided by HGNC
Official Full Name
SDA1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25537
See related
Ensembl:ENSG00000198301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 19.5), thyroid (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See SDAD1 in Genome Data Viewer
Location:
4q21.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (75949906..75990962, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76871064..76912115, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377285 Neighboring gene protein phosphatase with EF-hand domain 2 Neighboring gene N-acylethanolamine acid amidase Neighboring gene SDAD1 antisense RNA 1 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene ADP-ribosyltransferase 3 Neighboring gene C-X-C motif chemokine ligand 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10498, DKFZp686E22207

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
ribosomal large subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ribosomal large subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein SDA1 homolog
Names
SDA1 domain-containing protein 1
nucleolar protein 130

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288983.1NP_001275912.1  protein SDA1 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK024031, AK300074, BU619826, CR749574, DB047277
    Consensus CDS
    CCDS75147.1
    UniProtKB/Swiss-Prot
    Q9NVU7
    UniProtKB/TrEMBL
    B4DT66, E7EW05
    Related
    ENSP00000379061.4, ENST00000395711.8
    Conserved Domains (2) summary
    pfam05285
    Location:372647
    SDA1; SDA1
    pfam08158
    Location:62100
    NUC130_3NT; NUC130/3NT domain
  2. NM_001288984.1NP_001275913.1  protein SDA1 homolog isoform 3

    See identical proteins and their annotated locations for NP_001275913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK024031, AK300074, BJ989617, BU619826, CR749574, DB047277
    UniProtKB/Swiss-Prot
    Q9NVU7
    UniProtKB/TrEMBL
    B4DT66
    Conserved Domains (1) summary
    pfam05285
    Location:312587
    SDA1; SDA1
  3. NM_018115.4NP_060585.2  protein SDA1 homolog isoform 1

    See identical proteins and their annotated locations for NP_060585.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK001360, BC048351, BJ989617, BU619826
    Consensus CDS
    CCDS3573.2
    UniProtKB/Swiss-Prot
    Q9NVU7
    Related
    ENSP00000348596.5, ENST00000356260.10
    Conserved Domains (2) summary
    pfam05285
    Location:409684
    SDA1; SDA1
    pfam08158
    Location:62111
    NUC130_3NT; NUC130/3NT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    75949906..75990962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263102.4XP_005263159.1  protein SDA1 homolog isoform X1

    Conserved Domains (2) summary
    pfam05285
    Location:384659
    SDA1; SDA1
    pfam08158
    Location:3786
    NUC130_3NT; NUC130/3NT domain
  2. XM_005263105.4XP_005263162.1  protein SDA1 homolog isoform X2

    See identical proteins and their annotated locations for XP_005263162.1

    UniProtKB/Swiss-Prot
    Q9NVU7
    Conserved Domains (1) summary
    pfam05285
    Location:312587
    SDA1; SDA1
  3. XM_017008354.2XP_016863843.1  protein SDA1 homolog isoform X3

    Conserved Domains (1) summary
    pfam05285
    Location:143418
    SDA1; SDA1
  4. XM_024454119.1XP_024309887.1  protein SDA1 homolog isoform X3

    Conserved Domains (1) summary
    pfam05285
    Location:143418
    SDA1; SDA1
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