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DALRD3 DALR anticodon binding domain containing 3 [ Homo sapiens (human) ]

Gene ID: 55152, updated on 10-Dec-2019

Summary

Official Symbol
DALRD3provided by HGNC
Official Full Name
DALR anticodon binding domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25536
See related
Ensembl:ENSG00000178149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in testis (RPKM 22.8), prostate (RPKM 21.2) and 25 other tissues See more
Orthologs

Genomic context

See DALRD3 in Genome Data Viewer
Location:
3p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49015399..49021251, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49052832..49058504, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene WD repeat domain 6 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 Neighboring gene microRNA 425 Neighboring gene microRNA 191 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10496

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
arginine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
arginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DALR anticodon-binding domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033126.1 RefSeqGene

    Range
    7492..10584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009996.3NP_001009996.1  DALR anticodon-binding domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001009996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC047683, DB045082
    Consensus CDS
    CCDS33754.1
    UniProtKB/Swiss-Prot
    Q5D0E6
    Related
    ENSP00000344989.4, ENST00000341949.9
    Conserved Domains (1) summary
    smart00836
    Location:403543
    DALR_1; DALR anticodon binding domain
  2. NM_001276405.1NP_001263334.1  DALR anticodon-binding domain-containing protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at an internal exon in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC137630, BC054493, DB045082
    Consensus CDS
    CCDS63632.1
    UniProtKB/Swiss-Prot
    Q5D0E6
    Related
    ENSP00000410623.2, ENST00000441576.6
  3. NM_018114.5NP_060584.3  DALR anticodon-binding domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_060584.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC137630, AK093204, BC054493, HY047953
    Consensus CDS
    CCDS2783.1
    UniProtKB/Swiss-Prot
    Q5D0E6
    Related
    ENSP00000323265.5, ENST00000313778.9
    Conserved Domains (1) summary
    smart00836
    Location:236376
    DALR_1; DALR anticodon binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49015399..49021251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006723.1XP_016862212.1  DALR anticodon-binding domain-containing protein 3 isoform X4

    Related
    ENSP00000403770.1, ENST00000440857.5
  2. XM_011533892.2XP_011532194.1  DALR anticodon-binding domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011532194.1

    Conserved Domains (1) summary
    smart00836
    Location:236408
    DALR_1; DALR anticodon binding domain
  3. XM_006713219.2XP_006713282.1  DALR anticodon-binding domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006713282.1

    Conserved Domains (1) summary
    smart00836
    Location:236408
    DALR_1; DALR anticodon binding domain
  4. XM_011533893.2XP_011532195.1  DALR anticodon-binding domain-containing protein 3 isoform X5

    Related
    ENSP00000397385.2, ENST00000420952.2
  5. XM_005265269.4XP_005265326.1  DALR anticodon-binding domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    smart00836
    Location:403575
    DALR_1; DALR anticodon binding domain
  6. XM_011533891.2XP_011532193.1  DALR anticodon-binding domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    cl12020
    Location:403464
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RNA

  1. XR_940464.3 RNA Sequence

    Related
    ENST00000484831.5
  2. XR_001740191.2 RNA Sequence

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