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ZDHHC4 zinc finger DHHC-type palmitoyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 55146, updated on 26-Oct-2022

Summary

Official Symbol
ZDHHC4provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:18471
See related
Ensembl:ENSG00000136247 AllianceGenome:HGNC:18471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF374
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Located in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 21.7), testis (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZDHHC4 in Genome Data Viewer
Location:
7p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6577454..6589374)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6696620..6708547)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6617085..6629005)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 34 Neighboring gene uncharacterized LOC101927325 Neighboring gene Grid2 interacting protein Neighboring gene uncharacterized LOC124901582 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene zinc finger protein 853

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10479

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC4
Names
DHHC-4
probable palmitoyltransferase ZDHHC4
zinc finger DHHC domain-containing protein 4
zinc finger DHHC-type containing 4
zinc finger protein 374
zinc finger, DHHC domain containing 4
NP_001127859.1
NP_001127860.1
NP_001127861.1
NP_001358221.1
NP_001358222.1
NP_001358223.1
NP_001358224.1
NP_001358225.1
NP_001358226.1
NP_001358227.1
NP_001358228.1
NP_060576.1
XP_005249853.1
XP_047276520.1
XP_047276521.1
XP_047276522.1
XP_047276523.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134387.2NP_001127859.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277, BQ925460, CN365375
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9, Q9NPG8
    UniProtKB/TrEMBL
    A0A024QZS8
    Related
    ENSP00000379941.2, ENST00000396713.6
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  2. NM_001134388.2NP_001127860.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277, BQ925460
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9, Q9NPG8
    UniProtKB/TrEMBL
    A0A024QZS8
    Related
    ENSP00000379935.2, ENST00000396707.6
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  3. NM_001134389.2NP_001127861.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_001127861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, BQ185277
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9, Q9NPG8
    UniProtKB/TrEMBL
    A0A024QZS8
    Related
    ENSP00000337475.6, ENST00000335965.11
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  4. NM_001371292.1NP_001358221.1  palmitoyltransferase ZDHHC4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (a).
    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:151307
    DHHC; DHHC palmitoyltransferase
  5. NM_001371293.1NP_001358222.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  6. NM_001371294.1NP_001358223.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  7. NM_001371295.1NP_001358224.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  8. NM_001371296.1NP_001358225.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  9. NM_001371297.1NP_001358226.1  palmitoyltransferase ZDHHC4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
    Related
    ENSP00000379937.1, ENST00000396709.5
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  10. NM_001371298.1NP_001358227.1  palmitoyltransferase ZDHHC4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:131272
    DHHC; DHHC palmitoyltransferase
  11. NM_001371299.1NP_001358228.1  palmitoyltransferase ZDHHC4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC079742
    Conserved Domains (1) summary
    pfam01529
    Location:151232
    DHHC; DHHC palmitoyltransferase
  12. NM_018106.4NP_060576.1  palmitoyltransferase ZDHHC4 isoform b

    See identical proteins and their annotated locations for NP_060576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
    Source sequence(s)
    AC079742, AK001341, AK223532, BQ185277
    Consensus CDS
    CCDS5352.1
    UniProtKB/Swiss-Prot
    Q9H0R9, Q9NPG8
    UniProtKB/TrEMBL
    A0A024QZS8
    Related
    ENSP00000385027.3, ENST00000405731.7
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_163912.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079742
  2. NR_163913.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079742

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6577454..6589374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420565.1XP_047276521.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
  2. XM_047420564.1XP_047276520.1  palmitoyltransferase ZDHHC4 isoform X1

    UniProtKB/Swiss-Prot
    Q9H0R9
    UniProtKB/TrEMBL
    A0A024QZS8
  3. XM_047420566.1XP_047276522.1  palmitoyltransferase ZDHHC4 isoform X2

  4. XM_005249796.4XP_005249853.1  palmitoyltransferase ZDHHC4 isoform X1

    See identical proteins and their annotated locations for XP_005249853.1

    UniProtKB/Swiss-Prot
    Q9H0R9, Q9NPG8
    UniProtKB/TrEMBL
    A0A024QZS8
    Conserved Domains (1) summary
    pfam01529
    Location:151292
    DHHC; DHHC palmitoyltransferase
  5. XM_047420567.1XP_047276523.1  palmitoyltransferase ZDHHC4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6696620..6708547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)