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FIGN fidgetin, microtubule severing factor [ Homo sapiens (human) ]

Gene ID: 55137, updated on 13-Mar-2020

Summary

Official Symbol
FIGNprovided by HGNC
Official Full Name
fidgetin, microtubule severing factorprovided by HGNC
Primary source
HGNC:HGNC:13285
See related
Ensembl:ENSG00000182263 MIM:605295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 1.1), fat (RPKM 1.0) and 25 other tissues See more
Orthologs

Genomic context

See FIGN in Genome Data Viewer
Location:
2q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (163602611..163736155, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (164461447..164592618, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985829 Neighboring gene uncharacterized LOC105373728 Neighboring gene VISTA enhancer hs170 Neighboring gene uncharacterized LOC107985957 Neighboring gene VISTA enhancer hs640 Neighboring gene VISTA enhancer hs421 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients.
NHGRI GWA Catalog
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule severing IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321825.2NP_001308754.1  fidgetin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092684, AC093727
    Conserved Domains (3) summary
    smart00382
    Location:508643
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:511641
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:712745
    Vps4_C; Vps4 C terminal oligomerization domain
  2. NM_018086.4NP_060556.2  fidgetin isoform 1

    See identical proteins and their annotated locations for NP_060556.2

    Status: VALIDATED

    Source sequence(s)
    AC092684, AC093727, AK125324, BX649105
    Consensus CDS
    CCDS2221.2
    UniProtKB/Swiss-Prot
    Q5HY92
    Related
    ENSP00000333836.3, ENST00000333129.4
    Conserved Domains (1) summary
    COG0464
    Location:471746
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    163602611..163736155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511389.2XP_011509691.1  fidgetin isoform X1

    See identical proteins and their annotated locations for XP_011509691.1

    Conserved Domains (3) summary
    smart00382
    Location:545680
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:548678
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:749782
    Vps4_C; Vps4 C terminal oligomerization domain
  2. XM_017004419.1XP_016859908.1  fidgetin isoform X1

    Conserved Domains (3) summary
    smart00382
    Location:545680
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:548678
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:749782
    Vps4_C; Vps4 C terminal oligomerization domain
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