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FIGN fidgetin, microtubule severing factor [ Homo sapiens (human) ]

Gene ID: 55137, updated on 5-Aug-2022

Summary

Official Symbol
FIGNprovided by HGNC
Official Full Name
fidgetin, microtubule severing factorprovided by HGNC
Primary source
HGNC:HGNC:13285
See related
Ensembl:ENSG00000182263 MIM:605295; AllianceGenome:HGNC:13285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.1), fat (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See FIGN in Genome Data Viewer
Location:
2q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (163602611..163736008, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (164059859..164193293, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (164459121..164592518, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985829 Neighboring gene uncharacterized LOC105373728 Neighboring gene VISTA enhancer hs170 Neighboring gene Sharpr-MPRA regulatory region 10417 Neighboring gene uncharacterized LOC107985957 Neighboring gene VISTA enhancer hs640 Neighboring gene VISTA enhancer hs421 Neighboring gene Sharpr-MPRA regulatory region 13497

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients.
EBI GWAS Catalog
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321825.2NP_001308754.1  fidgetin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092684, AC093727
    Conserved Domains (1) summary
    COG0464
    Location:460735
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. NM_018086.4NP_060556.2  fidgetin isoform 1

    See identical proteins and their annotated locations for NP_060556.2

    Status: VALIDATED

    Source sequence(s)
    AC092684, AC093727, AK125324, BX649105
    Consensus CDS
    CCDS2221.2
    UniProtKB/Swiss-Prot
    Q5HY92, Q9NVZ9
    Related
    ENSP00000333836.3, ENST00000333129.4
    Conserved Domains (1) summary
    COG0464
    Location:471746
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    163602611..163736008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444863.1XP_047300819.1  fidgetin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    164059859..164193293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)