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SLFN12 schlafen family member 12 [ Homo sapiens (human) ]

Gene ID: 55106, updated on 21-May-2024

Summary

Official Symbol
SLFN12provided by HGNC
Official Full Name
schlafen family member 12provided by HGNC
Primary source
HGNC:HGNC:25500
See related
Ensembl:ENSG00000172123 MIM:614955; AllianceGenome:HGNC:25500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLFN3
Summary
Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 3.5), urinary bladder (RPKM 3.0) and 24 other tissues See more
Orthologs
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Genomic context

See SLFN12 in Genome Data Viewer
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35410922..35433174, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36351811..36381711, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33737941..33760193, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene UFM1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33720941-33721442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33721443-33721942 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:33735070-33735283 Neighboring gene DTW domain containing 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12067 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:33759523-33760722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12069 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:33760881-33761606 Neighboring gene schlafen family member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8437 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr17:33776099-33776600 and GRCh37_chr17:33776601-33777100 Neighboring gene adenylosuccinate synthase 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8438

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • FLJ10260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA nuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289009.2NP_001275938.1  ribonuclease SLFN12

    See identical proteins and their annotated locations for NP_001275938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC060766, AK291826, CB045471
    Consensus CDS
    CCDS11295.1
    UniProtKB/Swiss-Prot
    A8K711, Q8IYM2, Q9NP47
    Related
    ENSP00000394903.2, ENST00000452764.3
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  2. NM_018042.5NP_060512.3  ribonuclease SLFN12

    See identical proteins and their annotated locations for NP_060512.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK001122, BC035605, CB045471
    Consensus CDS
    CCDS11295.1
    UniProtKB/Swiss-Prot
    A8K711, Q8IYM2, Q9NP47
    Related
    ENSP00000302077.5, ENST00000304905.10
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35410922..35433174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257995.6XP_005258052.1  ribonuclease SLFN12 isoform X1

    See identical proteins and their annotated locations for XP_005258052.1

    UniProtKB/Swiss-Prot
    A8K711, Q8IYM2, Q9NP47
    Related
    ENSP00000398315.3, ENST00000447040.7
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  2. XM_024450822.2XP_024306590.1  ribonuclease SLFN12 isoform X1

    UniProtKB/Swiss-Prot
    A8K711, Q8IYM2, Q9NP47
    Related
    ENSP00000404175.2, ENST00000445092.6
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36351811..36381711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316600.1XP_054172575.1  ribonuclease SLFN12 isoform X1

  2. XM_054316599.1XP_054172574.1  ribonuclease SLFN12 isoform X1

  3. XM_054316598.1XP_054172573.1  ribonuclease SLFN12 isoform X1

RNA

  1. XR_008484855.1 RNA Sequence

  2. XR_008484854.1 RNA Sequence

  3. XR_008484852.1 RNA Sequence

  4. XR_008484856.1 RNA Sequence

  5. XR_008484853.1 RNA Sequence