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SLFN12 schlafen family member 12 [ Homo sapiens (human) ]

Gene ID: 55106, updated on 24-Nov-2020

Summary

Official Symbol
SLFN12provided by HGNC
Official Full Name
schlafen family member 12provided by HGNC
Primary source
HGNC:HGNC:25500
See related
Ensembl:ENSG00000172123 MIM:614955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLFN3
Expression
Ubiquitous expression in spleen (RPKM 3.5), urinary bladder (RPKM 3.0) and 24 other tissues See more
Orthologs

Genomic context

See SLFN12 in Genome Data Viewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35407171..35433310, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33738079..33760302, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene schlafen family member 11 Neighboring gene uncharacterized LOC105371933 Neighboring gene UFM1 pseudogene 2 Neighboring gene DTW domain containing 2 pseudogene Neighboring gene schlafen family member 13 Neighboring gene adenylosuccinate synthase 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ10260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289009.2NP_001275938.1  schlafen family member 12

    See identical proteins and their annotated locations for NP_001275938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC060766, AK291826, CB045471
    Consensus CDS
    CCDS11295.1
    UniProtKB/Swiss-Prot
    Q8IYM2
    Related
    ENSP00000394903.2, ENST00000452764.3
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  2. NM_018042.5NP_060512.3  schlafen family member 12

    See identical proteins and their annotated locations for NP_060512.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK001122, BC035605, CB045471
    Consensus CDS
    CCDS11295.1
    UniProtKB/Swiss-Prot
    Q8IYM2
    Related
    ENSP00000302077.5, ENST00000304905.9
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35407171..35433310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450822.1XP_024306590.1  schlafen family member 12 isoform X1

    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  2. XM_017024809.2XP_016880298.1  schlafen family member 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8IYM2
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  3. XM_011524967.3XP_011523269.1  schlafen family member 12 isoform X1

    See identical proteins and their annotated locations for XP_011523269.1

    UniProtKB/Swiss-Prot
    Q8IYM2
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  4. XM_005257995.5XP_005258052.1  schlafen family member 12 isoform X1

    See identical proteins and their annotated locations for XP_005258052.1

    UniProtKB/Swiss-Prot
    Q8IYM2
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  5. XM_017024810.2XP_016880299.1  schlafen family member 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8IYM2
    Conserved Domains (1) summary
    cl27772
    Location:35341
    B3R; Poxviridae B3 protein
  6. XM_017024811.2XP_016880300.1  schlafen family member 12 isoform X2

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