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SAMD4B sterile alpha motif domain containing 4B [ Homo sapiens (human) ]

Gene ID: 55095, updated on 23-Nov-2021

Summary

Official Symbol
SAMD4Bprovided by HGNC
Official Full Name
sterile alpha motif domain containing 4Bprovided by HGNC
Primary source
HGNC:HGNC:25492
See related
Ensembl:ENSG00000179134 MIM:619231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMGB; Smaug2
Expression
Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See SAMD4B in Genome Data Viewer
Location:
19q13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39342421..39390748)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39833061..39875528)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene glia maturation factor gamma Neighboring gene RNA, 7SL, cytoplasmic 566, pseudogene Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene mediator complex subunit 29 Neighboring gene ZFP36 ring finger protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10211, MGC99832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Smaug homolog 2
Names
SAM domain-containing protein 4B
smaug 2
smaug homolog B
sterile alpha motif domain-containing protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303614.2NP_001290543.1  protein Smaug homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001290543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (b) is shorter, and has a distinct C-terminus, compared to isoform a. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Consensus CDS
    CCDS77295.1
    UniProtKB/Swiss-Prot
    Q5PRF9
    UniProtKB/TrEMBL
    M0QZ22, Q66K25, Q8IXP7
    Related
    ENSP00000470237.1, ENST00000598913.5
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  2. NM_001384565.1NP_001371494.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  3. NM_001384566.1NP_001371495.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  4. NM_001384568.1NP_001371497.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  5. NM_001384569.1NP_001371498.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  6. NM_001384570.1NP_001371499.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  7. NM_001384571.1NP_001371500.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  8. NM_001384573.1NP_001371502.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  9. NM_001384574.2NP_001371503.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  10. NM_001384575.1NP_001371504.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  11. NM_001384576.1NP_001371505.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  12. NM_001384577.1NP_001371506.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Related
    ENSP00000484229.1, ENST00000610417.4
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  13. NM_001384578.1NP_001371507.1  protein Smaug homolog 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  14. NM_001384580.1NP_001371509.1  protein Smaug homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  15. NM_001384581.1NP_001371510.1  protein Smaug homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  16. NM_001384582.1NP_001371511.1  protein Smaug homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  17. NM_001384583.1NP_001371512.1  protein Smaug homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  18. NM_001384584.1NP_001371513.1  protein Smaug homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  19. NM_001384585.1NP_001371514.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes isoform c.
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  20. NM_001384586.1NP_001371515.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  21. NM_001384587.1NP_001371516.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  22. NM_001384588.1NP_001371517.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  23. NM_001384589.1NP_001371518.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  24. NM_001384590.1NP_001371519.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  25. NM_001384591.1NP_001371520.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  26. NM_001384592.1NP_001371521.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  27. NM_001384593.1NP_001371522.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  28. NM_001384594.1NP_001371523.1  protein Smaug homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  29. NM_001384595.1NP_001371524.1  protein Smaug homolog 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  30. NM_018028.4NP_060498.2  protein Smaug homolog 2 isoform a

    See identical proteins and their annotated locations for NP_060498.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 3-14 all encode the same isoform (a).
    Source sequence(s)
    AC005239, AC011445
    Consensus CDS
    CCDS33020.1
    UniProtKB/Swiss-Prot
    Q5PRF9
    UniProtKB/TrEMBL
    A0A024R0N7
    Related
    ENSP00000317224.5, ENST00000314471.10
    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily

RNA

  1. NR_169271.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445
  2. NR_169272.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445
  3. NR_169273.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445
  4. NR_169274.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005239, AC011445

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39342421..39390748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527062.2XP_011525364.1  protein Smaug homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011525364.1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
  2. XM_011527057.2XP_011525359.1  protein Smaug homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011525359.1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
  3. XM_017026919.1XP_016882408.1  protein Smaug homolog 2 isoform X1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
  4. XM_017026923.2XP_016882412.1  protein Smaug homolog 2 isoform X3

    Conserved Domains (1) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
  5. XM_011527060.3XP_011525362.1  protein Smaug homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011525362.1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
  6. XM_017026918.1XP_016882407.1  protein Smaug homolog 2 isoform X1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
  7. XM_011527061.3XP_011525363.1  protein Smaug homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011525363.1

    Conserved Domains (2) summary
    cd09557
    Location:296358
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:301359
    SAM; Sterile alpha motif
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