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PPP1R3D protein phosphatase 1 regulatory subunit 3D [ Homo sapiens (human) ]

Gene ID: 5509, updated on 11-Jun-2021

Summary

Official Symbol
PPP1R3Dprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Dprovided by HGNC
Primary source
HGNC:HGNC:9294
See related
Ensembl:ENSG00000132825 MIM:603326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R6
Summary
Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See PPP1R3D in Genome Data Viewer
Location:
20q13.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (59936663..59940305, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58511718..58515360, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 141 pseudogene Neighboring gene synaptonemal complex protein 2 Neighboring gene family with sequence similarity 217 member B Neighboring gene cadherin 26 Neighboring gene long intergenic non-protein coding RNA 2910

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781L2441

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in glycogen granule IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3D
Names
PP1 subunit R6
protein phosphatase 1 regulatory subunit 6
protein phosphatase 1, regulatory (inhibitor) subunit 3D
protein phosphatase 1, regulatory subunit 6, spinophilin
protein phosphatase 1-binding subunit R6
NP_006233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006242.4NP_006233.1  protein phosphatase 1 regulatory subunit 3D

    See identical proteins and their annotated locations for NP_006233.1

    Status: REVIEWED

    Source sequence(s)
    AL109928
    Consensus CDS
    CCDS13483.1
    UniProtKB/Swiss-Prot
    O95685
    UniProtKB/TrEMBL
    Q86X09
    Related
    ENSP00000360035.3, ENST00000370996.5
    Conserved Domains (1) summary
    pfam03370
    Location:171277
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    59936663..59940305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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