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PPP1R3C protein phosphatase 1 regulatory subunit 3C [ Homo sapiens (human) ]

Gene ID: 5507, updated on 2-Nov-2024

Summary

Official Symbol
PPP1R3Cprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Cprovided by HGNC
Primary source
HGNC:HGNC:9293
See related
Ensembl:ENSG00000119938 MIM:602999; AllianceGenome:HGNC:9293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTG; PPP1R5
Summary
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
Expression
Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues See more
Orthologs
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Genomic context

See PPP1R3C in Genome Data Viewer
Location:
10q23.32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91628442..91633071, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92511668..92516296, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93388199..93392828, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene HECTD2 antisense RNA 1 Neighboring gene uncharacterized LOC105378433 Neighboring gene ribosomal protein S27 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 13147 Neighboring gene VISTA enhancer hs1950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93392459-93392960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93392961-93393460 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:93412611-93413810 Neighboring gene uncharacterized LOC107984253 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 15620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3C
Names
PP1 subunit R5
Phosphatase 1, regulatory inhibitor subunit 5
protein phosphatase 1 regulatory subunit 5
protein phosphatase 1, regulatory (inhibitor) subunit 3C
protein targeting to glycogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051567.1 RefSeqGene

    Range
    5031..9660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005398.7NP_005389.1  protein phosphatase 1 regulatory subunit 3C

    See identical proteins and their annotated locations for NP_005389.1

    Status: REVIEWED

    Source sequence(s)
    AI766011, AK313149, BC012625, BP202053, H14591
    Consensus CDS
    CCDS7416.1
    UniProtKB/Swiss-Prot
    B2R7X0, O95686, Q9UQK1
    UniProtKB/TrEMBL
    B4DRR5, E7EMI6
    Related
    ENSP00000238994.5, ENST00000238994.6
    Conserved Domains (1) summary
    pfam03370
    Location:153256
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    91628442..91633071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    92511668..92516296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)