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PPP1R3C protein phosphatase 1 regulatory subunit 3C [ Homo sapiens (human) ]

Gene ID: 5507, updated on 18-Aug-2020

Summary

Official Symbol
PPP1R3Cprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 3Cprovided by HGNC
Primary source
HGNC:HGNC:9293
See related
Ensembl:ENSG00000119938 MIM:602999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTG; PPP1R5
Summary
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
Expression
Broad expression in heart (RPKM 69.5), esophagus (RPKM 32.0) and 14 other tissues See more
Orthologs

Genomic context

See PPP1R3C in Genome Data Viewer
Location:
10q23.32
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (91628442..91633071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93388197..93392858, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene HECTD2 antisense RNA 1 Neighboring gene uncharacterized LOC105378433 Neighboring gene VISTA enhancer hs1950 Neighboring gene uncharacterized LOC107984253 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glycogen biosynthetic process TAS
Traceable Author Statement
more info
 
glycogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 3C
Names
PP1 subunit R5
Phosphatase 1, regulatory inhibitor subunit 5
protein phosphatase 1 regulatory subunit 5
protein phosphatase 1, regulatory (inhibitor) subunit 3C
protein targeting to glycogen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051567.1 RefSeqGene

    Range
    5031..9660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005398.7NP_005389.1  protein phosphatase 1 regulatory subunit 3C

    See identical proteins and their annotated locations for NP_005389.1

    Status: REVIEWED

    Source sequence(s)
    AI766011, AK313149, BC012625, BP202053, H14591
    Consensus CDS
    CCDS7416.1
    UniProtKB/Swiss-Prot
    Q9UQK1
    Related
    ENSP00000238994.5, ENST00000238994.6
    Conserved Domains (1) summary
    pfam03370
    Location:153256
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    91628442..91633071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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