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SLC52A1 solute carrier family 52 member 1 [ Homo sapiens (human) ]

Gene ID: 55065, updated on 25-Jan-2022

Summary

Official Symbol
SLC52A1provided by HGNC
Official Full Name
solute carrier family 52 member 1provided by HGNC
Primary source
HGNC:HGNC:30225
See related
Ensembl:ENSG00000132517 MIM:607883; AllianceGenome:HGNC:30225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR2; RFT1; RBFVD; RFVT1; hRFT1; GPCR42; GPR172B; huPAR-2
Summary
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Expression
Biased expression in duodenum (RPKM 20.9), placenta (RPKM 16.1) and 2 other tissues See more
Orthologs
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Genomic context

See SLC52A1 in Genome Data Viewer
Location:
17p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (5032602..5035426, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4935897..4938721, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 1C Neighboring gene KIF1C antisense RNA 1 Neighboring gene uncharacterized LOC105371502 Neighboring gene uncharacterized LOC105371501 Neighboring gene Sharpr-MPRA regulatory region 9431 Neighboring gene zinc finger with KRAB and SCAN domains 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10060

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables riboflavin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables riboflavin transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in riboflavin metabolic process TAS
Traceable Author Statement
more info
 
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in riboflavin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 52, riboflavin transporter, member 1
Names
G protein-coupled receptor 172B
G-protein coupled receptor GPCR42
PERV-A receptor 2
porcine endogenous retrovirus A receptor 2
solute carrier family 52 (riboflavin transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033117.1 RefSeqGene

    Range
    5001..7831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104577.2NP_001098047.1  solute carrier family 52, riboflavin transporter, member 1 precursor

    See identical proteins and their annotated locations for NP_001098047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK000922, AY070775, BC092473, BU752646, DA383729
    Consensus CDS
    CCDS11066.1
    UniProtKB/Swiss-Prot
    Q9NWF4
    Related
    ENSP00000399979.1, ENST00000424747.1
    Conserved Domains (1) summary
    pfam06237
    Location:280374
    DUF1011; Protein of unknown function (DUF1011)
  2. NM_017986.4NP_060456.3  solute carrier family 52, riboflavin transporter, member 1 precursor

    See identical proteins and their annotated locations for NP_060456.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK000922, AY070775, BC092473, BU752646, DA383729
    Consensus CDS
    CCDS11066.1
    UniProtKB/Swiss-Prot
    Q9NWF4
    Related
    ENSP00000254853.5, ENST00000254853.10
    Conserved Domains (1) summary
    pfam06237
    Location:280374
    DUF1011; Protein of unknown function (DUF1011)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    5032602..5035426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523951.2XP_011522253.1  solute carrier family 52, riboflavin transporter, member 1 isoform X1

    See identical proteins and their annotated locations for XP_011522253.1

    UniProtKB/Swiss-Prot
    Q9NWF4
    Conserved Domains (1) summary
    pfam06237
    Location:280374
    DUF1011; Protein of unknown function (DUF1011)
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