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TRMT12 tRNA methyltransferase 12 homolog [ Homo sapiens (human) ]

Gene ID: 55039, updated on 23-Nov-2021

Summary

Official Symbol
TRMT12provided by HGNC
Official Full Name
tRNA methyltransferase 12 homologprovided by HGNC
Primary source
HGNC:HGNC:26091
See related
Ensembl:ENSG00000183665 MIM:611244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TYW2; TRM12
Summary
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Orthologs
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Genomic context

See TRMT12 in Genome Data Viewer
Location:
8q24.13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (124450820..124453026)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125463061..125465267)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene transcription factor SOX-2-like Neighboring gene transmembrane protein 65 Neighboring gene Sharpr-MPRA regulatory region 2045 Neighboring gene RNF139 divergent transcript Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20772

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA wybutosine-synthesizing protein 2 homolog
Names
alpha-amino-alpha-carboxypropyl transferase TYW2
homolog of yeast tRNA methyltransferase
tRNA methyltranferase 12 homolog
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
tRNA-yW-synthesizing protein 2
NP_060426.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017956.4NP_060426.2  tRNA wybutosine-synthesizing protein 2 homolog

    See identical proteins and their annotated locations for NP_060426.2

    Status: VALIDATED

    Source sequence(s)
    AA608716, AK222727, BP342608
    Consensus CDS
    CCDS6349.1
    UniProtKB/Swiss-Prot
    Q53H54
    Related
    ENSP00000329858.3, ENST00000328599.4
    Conserved Domains (2) summary
    COG2520
    Location:31441
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
    pfam12847
    Location:234336
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    124450820..124453026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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