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C1orf159 chromosome 1 open reading frame 159 [ Homo sapiens (human) ]

Gene ID: 54991, updated on 3-Nov-2024

Summary

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Official Symbol
C1orf159provided by HGNC
Official Full Name
chromosome 1 open reading frame 159provided by HGNC
Primary source
HGNC:HGNC:26062
See related
Ensembl:ENSG00000131591 AllianceGenome:HGNC:26062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 2.6), skin (RPKM 1.2) and 24 other tissues See more
Orthologs
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Genomic context

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See C1orf159 in Genome Data Viewer
Location:
1p36.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1081823..1116089, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (510436..544704, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1017203..1051469, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000857-1001357 Neighboring gene uncharacterized LOC105378948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1004678-1005443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1009379-1009878 Neighboring gene ring finger protein 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 31 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1015879-1016581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1016582-1017283 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1017301-1017480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1047169-1047670 Neighboring gene Sharpr-MPRA regulatory region 13538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 35 Neighboring gene uncharacterized LOC124903819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1058337-1059155 Neighboring gene uncharacterized LOC124903820 Neighboring gene CRISPRi-validated cis-regulatory element chr1.97 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 37 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 39 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1073727-1074228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1074229-1074728 Neighboring gene long intergenic non-protein coding RNA 1342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1076651-1077172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  2. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20584, FLJ21143, FLJ36119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C1orf159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330306.2 → NP_001317235.1  uncharacterized protein C1orf159 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL390719
    Consensus CDS
    CCDS81250.1
    UniProtKB/Swiss-Prot
    B3KQ46, Q5T2W6, Q6UX67, Q6ZR77, Q96HA4, Q9NWV0
    Related
    ENSP00000368644.1, ENST00000379339.5

  2. NM_001363525.2 → NP_001350454.1  uncharacterized protein C1orf159 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL390719
    Consensus CDS
    CCDS85917.1
    UniProtKB/TrEMBL
    Q5T2W9
    Related
    ENSP00000368624.1, ENST00000379320.5
    Conserved Domains (1) summary
    pfam14946
    Location:23 → 167
    DUF4501; Domain of unknown function (DUF4501)

  3. NM_017891.5 → NP_060361.4  uncharacterized protein C1orf159 isoform 2 precursor

    See identical proteins and their annotated locations for NP_060361.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK000591, BE280321, BM974309
    Consensus CDS
    CCDS7.2
    Related
    ENSP00000400736.2, ENST00000421241.7
    Conserved Domains (1) summary
    pfam14946
    Location:23 → 198
    DUF4501; Domain of unknown function (DUF4501)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1081823..1116089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    510436..544704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96HA4.2 GenPept UniProtKB/Swiss-Prot:Q96HA4

Gene LinkOut

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