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ODAM odontogenic, ameloblast associated [ Homo sapiens (human) ]

Gene ID: 54959, updated on 5-Aug-2022

Summary

Official Symbol
ODAMprovided by HGNC
Official Full Name
odontogenic, ameloblast associatedprovided by HGNC
Primary source
HGNC:HGNC:26043
See related
Ensembl:ENSG00000109205 MIM:614843; AllianceGenome:HGNC:26043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APIN
Summary
Involved in several processes, including positive regulation of GTPase activity; positive regulation of epithelial cell proliferation involved in wound healing; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward salivary gland (RPKM 78.4) See more
Orthologs
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Genomic context

See ODAM in Genome Data Viewer
Location:
4q13.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70195725..70204576)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73535038..73543889)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71061442..71070293)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene proline rich 27 Neighboring gene uncharacterized LOC105377270 Neighboring gene follicular dendritic cell secreted protein Neighboring gene casein kappa

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in supramolecular fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
odontogenic ameloblast-associated protein
Names
odontogenic, ameloblast asssociated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385579.1NP_001372508.1  odontogenic ameloblast-associated protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC105347
    Related
    ENSP00000426106.1, ENST00000514097.5
    Conserved Domains (1) summary
    pfam15424
    Location:16263
    ODAM; Odontogenic ameloblast-associated family
  2. NM_017855.4NP_060325.3  odontogenic ameloblast-associated protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_060325.3

    Status: VALIDATED

    Source sequence(s)
    AC105347
    Consensus CDS
    CCDS3536.2
    UniProtKB/Swiss-Prot
    A1E959, Q9NWZ9
    Related
    ENSP00000507531.1, ENST00000683306.1
    Conserved Domains (1) summary
    pfam15424
    Location:16279
    ODAM; Odontogenic ameloblast-associated family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    70195725..70204576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415864.1XP_047271820.1  odontogenic ameloblast-associated protein isoform X2

  2. XM_047415863.1XP_047271819.1  odontogenic ameloblast-associated protein isoform X1

    Related
    ENSP00000423070.2, ENST00000510709.6
  3. XM_047415865.1XP_047271821.1  odontogenic ameloblast-associated protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73535038..73543889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)