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PARP16 poly(ADP-ribose) polymerase family member 16 [ Homo sapiens (human) ]

Gene ID: 54956, updated on 21-Dec-2019

Summary

Official Symbol
PARP16provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 16provided by HGNC
Primary source
HGNC:HGNC:26040
See related
Ensembl:ENSG00000138617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD15; pART15; C15orf30
Expression
Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See PARP16 in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65231691..65286891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65550436..65579212, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cartilage intermediate layer protein Neighboring gene uncharacterized LOC112268147 Neighboring gene RNA, U6 small nuclear 686, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 24B Neighboring gene RNA, U5A small nuclear 1 Neighboring gene RNA, U5B small nuclear 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20509, FLJ25281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein auto-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum tubular network IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP16
Names
ADP-ribosyltransferase diphtheria toxin-like 15
PARP-16
mono [ADP-ribose] polymerase PARP16
poly [ADP-ribose] polymerase 16
NP_001303872.1
NP_001303873.1
NP_060321.3
XP_006720652.1
XP_006720653.1
XP_006720655.1
XP_011520044.1
XP_016877875.1
XP_016877876.1
XP_016877877.1
XP_016877878.1
XP_024305737.1
XP_024305738.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316943.2NP_001303872.1  protein mono-ADP-ribosyltransferase PARP16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516, BC031074, DA110379
    UniProtKB/Swiss-Prot
    Q8N5Y8
    Related
    ENSP00000496935.1, ENST00000649807.1
    Conserved Domains (2) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:150259
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. NM_001316944.2NP_001303873.1  protein mono-ADP-ribosyltransferase PARP16 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516
    Consensus CDS
    CCDS81897.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    UniProtKB/TrEMBL
    A0A024R5Y7
    Related
    ENSP00000396118.2, ENST00000444347.2
    Conserved Domains (1) summary
    pfam00644
    Location:62158
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  3. NM_017851.6NP_060321.3  protein mono-ADP-ribosyltransferase PARP16 isoform 1

    See identical proteins and their annotated locations for NP_060321.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068213, AK000516, BC006389, DA110379
    Consensus CDS
    CCDS10204.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    Related
    ENSP00000261888.6, ENST00000261888.10
    Conserved Domains (1) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65231691..65286891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720590.3XP_006720653.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

    Conserved Domains (2) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:150259
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. XM_006720589.3XP_006720652.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

    Conserved Domains (2) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:150259
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  3. XM_024449970.1XP_024305738.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

    Conserved Domains (1) summary
    pfam00644
    Location:108204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  4. XM_024449969.1XP_024305737.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

    Conserved Domains (1) summary
    pfam00644
    Location:59227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  5. XM_011521742.3XP_011520044.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

    Conserved Domains (2) summary
    pfam00644
    Location:59227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:104213
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  6. XM_017022387.2XP_016877876.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

  7. XM_017022386.2XP_016877875.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

  8. XM_006720592.3XP_006720655.1  protein mono-ADP-ribosyltransferase PARP16 isoform X3

    See identical proteins and their annotated locations for XP_006720655.1

    Conserved Domains (2) summary
    pfam00644
    Location:86254
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:131240
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  9. XM_017022389.2XP_016877878.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

  10. XM_017022388.2XP_016877877.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

RNA

  1. XR_001751341.2 RNA Sequence

  2. XR_001751342.2 RNA Sequence

  3. XR_001751343.2 RNA Sequence

  4. XR_429460.3 RNA Sequence

  5. XR_429459.3 RNA Sequence

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