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PARP16 poly(ADP-ribose) polymerase family member 16 [ Homo sapiens (human) ]

Gene ID: 54956, updated on 26-Oct-2022

Summary

Official Symbol
PARP16provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 16provided by HGNC
Primary source
HGNC:HGNC:26040
See related
Ensembl:ENSG00000138617 AllianceGenome:HGNC:26040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD15; pART15; C15orf30
Summary
Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 4.7), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See PARP16 in Genome Data Viewer
Location:
15q22.31
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65230917..65286883, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63067447..63096236, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65550437..65579221, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cartilage intermediate layer protein Neighboring gene RNA, U6 small nuclear 686, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 24B Neighboring gene RNA, U5A small nuclear 1 Neighboring gene RNA, U5B small nuclear 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20509, FLJ25281

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum tubular network IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP16
Names
ADP-ribosyltransferase diphtheria toxin-like 15
PARP-16
mono [ADP-ribose] polymerase PARP16
poly [ADP-ribose] polymerase 16
NP_001303872.1
NP_001303873.1
NP_060321.3
XP_006720652.1
XP_006720653.1
XP_006720655.1
XP_011520044.1
XP_016877875.1
XP_016877876.1
XP_016877877.1
XP_016877878.1
XP_024305737.1
XP_024305738.1
XP_047288731.1
XP_047288732.1
XP_047288733.1
XP_047288734.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316943.2NP_001303872.1  protein mono-ADP-ribosyltransferase PARP16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516, BC031074, DA110379
    Consensus CDS
    CCDS92018.1
    UniProtKB/Swiss-Prot
    Q8N5Y8, Q9NX03
    Related
    ENSP00000496935.1, ENST00000649807.2
    Conserved Domains (2) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00283
    Location:150259
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. NM_001316944.2NP_001303873.1  protein mono-ADP-ribosyltransferase PARP16 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068213, AK000516
    Consensus CDS
    CCDS81897.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    UniProtKB/TrEMBL
    A0A024R5Y7
    Related
    ENSP00000396118.2, ENST00000444347.2
    Conserved Domains (2) summary
    pfam00644
    Location:61158
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1164
    ARTD15_N; ARTD15 N-terminal domain
  3. NM_017851.6NP_060321.3  protein mono-ADP-ribosyltransferase PARP16 isoform 1

    See identical proteins and their annotated locations for NP_060321.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068213, AK000516, BC006389, DA110379
    Consensus CDS
    CCDS10204.1
    UniProtKB/Swiss-Prot
    Q8N5Y8
    Related
    ENSP00000261888.6, ENST00000261888.10
    Conserved Domains (1) summary
    pfam00644
    Location:95273
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65230917..65286883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432777.1XP_047288733.1  protein mono-ADP-ribosyltransferase PARP16 isoform X7

  2. XM_047432778.1XP_047288734.1  protein mono-ADP-ribosyltransferase PARP16 isoform X13

  3. XM_006720590.4XP_006720653.1  protein mono-ADP-ribosyltransferase PARP16 isoform X2

    Conserved Domains (2) summary
    pfam00644
    Location:102273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1190
    ARTD15_N; ARTD15 N-terminal domain
  4. XM_006720589.4XP_006720652.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

    Conserved Domains (2) summary
    pfam00644
    Location:102273
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1190
    ARTD15_N; ARTD15 N-terminal domain
  5. XM_047432775.1XP_047288731.1  protein mono-ADP-ribosyltransferase PARP16 isoform X3

  6. XM_047432776.1XP_047288732.1  protein mono-ADP-ribosyltransferase PARP16 isoform X4

  7. XM_024449969.2XP_024305737.1  protein mono-ADP-ribosyltransferase PARP16 isoform X10

    Conserved Domains (2) summary
    pfam00644
    Location:59227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1166
    ARTD15_N; ARTD15 N-terminal domain
  8. XM_024449970.2XP_024305738.1  protein mono-ADP-ribosyltransferase PARP16 isoform X14

    Conserved Domains (2) summary
    pfam00644
    Location:108204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1190
    ARTD15_N; ARTD15 N-terminal domain
  9. XM_017022387.3XP_016877876.1  protein mono-ADP-ribosyltransferase PARP16 isoform X9

    Conserved Domains (2) summary
    pfam00644
    Location:59227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1165
    ARTD15_N; ARTD15 N-terminal domain
  10. XM_011521742.4XP_011520044.1  protein mono-ADP-ribosyltransferase PARP16 isoform X8

    Conserved Domains (2) summary
    pfam00644
    Location:59227
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1166
    ARTD15_N; ARTD15 N-terminal domain
  11. XM_017022386.3XP_016877875.1  protein mono-ADP-ribosyltransferase PARP16 isoform X6

    Conserved Domains (1) summary
    cl00283
    Location:131240
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  12. XM_006720592.4XP_006720655.1  protein mono-ADP-ribosyltransferase PARP16 isoform X5

    See identical proteins and their annotated locations for XP_006720655.1

    Conserved Domains (2) summary
    pfam00644
    Location:86254
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1185
    ARTD15_N; ARTD15 N-terminal domain
  13. XM_017022389.3XP_016877878.1  protein mono-ADP-ribosyltransferase PARP16 isoform X12

    Conserved Domains (2) summary
    pfam00644
    Location:108204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1190
    ARTD15_N; ARTD15 N-terminal domain
  14. XM_017022388.3XP_016877877.1  protein mono-ADP-ribosyltransferase PARP16 isoform X11

    Conserved Domains (2) summary
    pfam00644
    Location:108204
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam18084
    Location:1190
    ARTD15_N; ARTD15 N-terminal domain

RNA

  1. XR_007064469.1 RNA Sequence

  2. XR_001751341.3 RNA Sequence

  3. XR_001751342.3 RNA Sequence

  4. XR_429460.4 RNA Sequence

  5. XR_429459.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    63067447..63096236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)