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TRNAU1AP tRNA selenocysteine 1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 54952, updated on 23-Nov-2021

Summary

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Official Symbol
TRNAU1APprovided by HGNC
Official Full Name
tRNA selenocysteine 1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:30813
See related
Ensembl:ENSG00000180098 MIM:619597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SECP43; PRO1902; TRSPAP1
Expression
Ubiquitous expression in lymph node (RPKM 5.3), urinary bladder (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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See TRNAU1AP in Genome Data Viewer
Location:
1p35.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28553085..28578545)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28879597..28905057)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 73B Neighboring gene small nucleolar RNA host gene 3 Neighboring gene regulator of chromosome condensation 1 Neighboring gene peroxiredoxin 3 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 11844 Neighboring gene Sharpr-MPRA regulatory region 11894 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway. Hu X, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29758194
  2. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. Ding F, et al. RNA, 1999 Dec. PMID 10606267, Free PMC Article
  3. Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43. Oudouhou F, et al. Biochemistry, 2017 May 2. PMID 28414460
  4. Supramolecular complexes mediate selenocysteine incorporation in vivo. Small-Howard A, et al. Mol Cell Biol, 2006 Mar. PMID 16508009, Free PMC Article
  5. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. Xu XM, et al. J Biol Chem, 2005 Dec 16. PMID 16230358

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Trnau1ap reduced cell migration and proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling pathway.
    Title: Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
  2. Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS, SECP43, SEPHS1, and SEPHS2); SECP43, which interacts with SEPSECS and SEPHS1, is a globular protein that forms oligomers in vivo.
    Title: Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.
  3. our studies delineating the multiple, coordinated protein-nucleic acid interactions between SECp43 and the selenoprotein cotranslational factors.
    Title: Supramolecular complexes mediate selenocysteine incorporation in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20503

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in selenocysteine incorporation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA selenocysteine 1-associated protein 1
Names
tRNA selenocysteine associated protein (SECP43)
tRNA selenocysteine-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017846.5 → NP_060316.1  tRNA selenocysteine 1-associated protein 1

    See identical proteins and their annotated locations for NP_060316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    BC000680, BI602122, BQ014404
    Consensus CDS
    CCDS324.1
    UniProtKB/Swiss-Prot
    Q9NX07
    Related
    ENSP00000362936.3, ENST00000373830.4
    Conserved Domains (3) summary
    pfam17654
    Location:205 → 284
    Trnau1ap; Selenocysteine tRNA 1 associated proteins
    cd12610
    Location:4 → 87
    RRM1_SECp43; RNA recognition motif 1 (RRM1) found in tRNA selenocysteine-associated protein 1 (SECp43)
    cd12612
    Location:95 → 176
    RRM2_SECp43; RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43)

RNA

  1. NR_003109.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC000680, BC039879, BI602122, BQ014404

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28553085..28578545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NX07.1 GenPept UniProtKB/Swiss-Prot:Q9NX07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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