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MRPL16 mitochondrial ribosomal protein L16 [ Homo sapiens (human) ]

Gene ID: 54948, updated on 2-Mar-2021

Summary

Official Symbol
MRPL16provided by HGNC
Official Full Name
mitochondrial ribosomal protein L16provided by HGNC
Primary source
HGNC:HGNC:14476
See related
Ensembl:ENSG00000166902 MIM:611829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L16mt; MRP-L16; PNAS-111
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 22.7), adrenal (RPKM 21.8) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL16 in Genome Data Viewer
Location:
11q12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (59806140..59810778, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59573613..59578251, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily V member 2 pseudogene Neighboring gene syntaxin 3 Neighboring gene fatty acid binding protein 5 pseudogene 7 Neighboring gene cobalamin binding intrinsic factor Neighboring gene transcobalamin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20484

Gene Ontology Provided by GOA

Function Evidence Code Pubs
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L16, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL16m
NP_060310.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017840.4NP_060310.1  39S ribosomal protein L16, mitochondrial

    See identical proteins and their annotated locations for NP_060310.1

    Status: REVIEWED

    Source sequence(s)
    AA454132, AB049642
    Consensus CDS
    CCDS7976.1
    UniProtKB/Swiss-Prot
    Q9NX20
    Related
    ENSP00000300151.4, ENST00000300151.5
    Conserved Domains (1) summary
    pfam00252
    Location:60183
    Ribosomal_L16; Ribosomal protein L16p/L10e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    59806140..59810778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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