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KANSL2 KAT8 regulatory NSL complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 54934, updated on 2-May-2024

Summary

Official Symbol
KANSL2provided by HGNC
Official Full Name
KAT8 regulatory NSL complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:26024
See related
Ensembl:ENSG00000139620 MIM:615488; AllianceGenome:HGNC:26024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSL2; C12orf41
Summary
Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 25.9), testis (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

Location:
12q13.11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48653211..48682238, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48615234..48644264, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49046994..49076021, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902928 Neighboring gene olfactory receptor family 11 subfamily M member 1 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 2C Neighboring gene microRNA 1291 Neighboring gene small nucleolar RNA, H/ACA box 2A Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4410 Neighboring gene MPRA-validated peak1722 silencer Neighboring gene MPRA-validated peak1723 silencer Neighboring gene cyclin T1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49110605-49111605 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49117404-49118078 Neighboring gene sperm microtubule inner protein 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161309-49161888 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49161889-49162469 Neighboring gene adenylate cyclase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12670, FLJ20436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 2
Names
NSL complex protein NSL2
non-specific lethal 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017822.4NP_060292.3  KAT8 regulatory NSL complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    BC009746, BG760446, BM672156, DA278834
    Consensus CDS
    CCDS44869.1
    UniProtKB/Swiss-Prot
    Q8N3B5, Q96CV0, Q9H9L4, Q9NX51
    UniProtKB/TrEMBL
    F8VXI8
    Related
    ENSP00000415436.3, ENST00000420613.7
    Conserved Domains (1) summary
    pfam13891
    Location:2891
    zf-C3Hc3H; Potential DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48653211..48682238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48615234..48644264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)