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KANSL2 KAT8 regulatory NSL complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 54934, updated on 22-Sep-2022

Summary

Official Symbol
KANSL2provided by HGNC
Official Full Name
KAT8 regulatory NSL complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:26024
See related
Ensembl:ENSG00000139620 MIM:615488; AllianceGenome:HGNC:26024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSL2; C12orf41
Summary
Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 25.9), testis (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See KANSL2 in Genome Data Viewer
Location:
12q13.11
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48653211..48682238, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48615234..48644264, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49046994..49076021, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902928 Neighboring gene olfactory receptor family 11 subfamily M member 1 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 2C Neighboring gene microRNA 1291 Neighboring gene small nucleolar RNA, H/ACA box 2A Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene cyclin T1 Neighboring gene testis expressed 49 Neighboring gene adenylate cyclase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12670, FLJ20436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 2
Names
NSL complex protein NSL2
non-specific lethal 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017822.4NP_060292.3  KAT8 regulatory NSL complex subunit 2

    See identical proteins and their annotated locations for NP_060292.3

    Status: VALIDATED

    Source sequence(s)
    BC009746, BG760446, BM672156, DA278834
    Consensus CDS
    CCDS44869.1
    UniProtKB/Swiss-Prot
    Q9H9L4, Q9NX51
    Related
    ENSP00000415436.3, ENST00000420613.7
    Conserved Domains (1) summary
    pfam13891
    Location:2891
    zf-C3Hc3H; Potential DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48653211..48682238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48615234..48644264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)