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BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 [ Homo sapiens (human) ]

Gene ID: 54928, updated on 1-Jun-2020

Summary

Official Symbol
BPNT2provided by HGNC
Official Full Name
3'(2'), 5'-bisphosphate nucleotidase 2provided by HGNC
Primary source
HGNC:HGNC:26019
See related
Ensembl:ENSG00000104331 MIM:614010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1
Summary
This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in fat (RPKM 26.8), adrenal (RPKM 24.2) and 25 other tissues See more
Orthologs

Genomic context

See BPNT2 in Genome Data Viewer
Location:
8q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (56957931..56993874, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (57870488..57906430, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene impact RWD domain protein pseudogene Neighboring gene RNA, U6 small nuclear 13, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 266 Neighboring gene long intergenic non-protein coding RNA 1606

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'(2'),5'-bisphosphate nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
3',5'-nucleotide bisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
3'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
chondrocyte development IEA
Inferred from Electronic Annotation
more info
 
chondroitin sulfate metabolic process IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi lumen TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
Names
Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
IMPase 3
golgi-resident PAP phosphatase
golgi-resident nucleotide phosphatase
inositol monophosphatase domain containing 1
inositol monophosphatase domain-containing protein 1
inositol-1(or 4)-monophosphatase 3
myo-inositol monophosphatase A3
phosphoadenosine phosphate 3'-nucleotidase
NP_060283.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031926.1 RefSeqGene

    Range
    5005..40941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017813.5NP_060283.3  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

    See identical proteins and their annotated locations for NP_060283.3

    Status: REVIEWED

    Source sequence(s)
    AC032027, AI095394, BC017797, BI601447
    Consensus CDS
    CCDS6169.1
    UniProtKB/Swiss-Prot
    Q9NX62
    UniProtKB/TrEMBL
    A0A024R7W0
    Related
    ENSP00000262644.4, ENST00000262644.9
    Conserved Domains (1) summary
    cd01640
    Location:66349
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    56957931..56993874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_928786.2 RNA Sequence

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